Severe skeletal fragility in SCN8A‐related developmental and epileptic encephalopathy
Abstract In this child with a phenotype compatible with the SCN8A gain‐of‐function spectrum, more than 20 bone fractures were documented. Together with previously reported cases, these observations raise the possibility that skeletal fragility may represent an underrecognized feature of the clinical spectrum associated with pathogenic SCN8A variants ...
Adélia Maria de Miranda Henriques‐Souza +1 more
wiley +1 more source
Fracture related infection complicating civilian ballistic wounds in the amasonian zone. [PDF]
Sylla K +14 more
europepmc +1 more source
Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley +5 more
wiley +1 more source
Intramedullary nailing with absorbable antibiotic-eluting ceramic for fracture-related infection prophylaxis in high-risk open fractures: a case series and technique. [PDF]
Sandilands SM, Daji AV.
europepmc +1 more source
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor +7 more
wiley +1 more source
A feasibility study of a novel closed flowing vacuum-assisted technique (CFVAT) in managing fracture-related infection with implant retention. [PDF]
Li Z +6 more
europepmc +1 more source
Fatalities within seven days after equine standing sedation: A prospective, multicentre study
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla +6 more
wiley +1 more source
Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection. [PDF]
Li J +16 more
europepmc +1 more source
Abstract Background FLow‐controlled EXpiration (FLEX) has been shown to significantly enhance oxygenation in horses under clinical and experimental conditions. Objectives To compare pulmonary gas exchange during early recovery following general anaesthesia in horses ventilated with FLEX compared with conventional intermittent positive pressure ...
Allison Mika +6 more
wiley +1 more source
Diagnosis of bacteraemia in neonatal foals using 16S rRNA high‐throughput sequencing
Abstract Background Sepsis is an important cause of morbidity and mortality in foals. Early diagnosis can improve outcome but is complicated by non‐specific clinical signs and delayed confirmation of infection via blood culture. Molecular assays represent a rapid and more sensitive alternative.
Flavie Payette +7 more
wiley +1 more source

