Results 121 to 130 of about 344,710 (298)

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

open access: yesAdvanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex   +4 more
wiley   +1 more source

Femoral neck morphology differentiates femoral neck from vertebral osteoporotic fracture

open access: yesReumatismo, 2003
Mineral density and bone geometry are the two main biomechanical factors related to bone resistance to stress. Objective: In this study we assess whether differences in the proximal femur geometry (PFG) characterize different types of osteoporotic ...
N. Malavolta   +3 more
doaj   +1 more source

VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing [PDF]

open access: yes, 2018
A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative.
Blunn, G   +3 more
core   +3 more sources

Si Inhibited Osteoclastogenesis: The Role of Fe and the Fenton Reaction

open access: yesAdvanced Healthcare Materials, EarlyView.
Silicate (Si) inhibition of osteoclastogenesis, is mediated by Fe. Si chemical interactions with Fe inhibit the Fenton reaction and intercellular ROS availability. This reduction in ROS availability inhibits osteoclastogenesis. The addition of Fe, in Si‐inhibited osteoclast cultures, restores the Fenton reaction, and osteoclastogenesis.
Yutong Li   +7 more
wiley   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum   +28 more
wiley   +1 more source

Fatigue‐Resistant Mechanoresponsive Color‐Changing Hydrogels for Vision‐Based Tactile Robots

open access: yesAdvanced Materials, EarlyView.
Mechanoresponsive color‐changing materials that can reversibly and resiliently change color in response to stress are highly desirable for diverse technologies in optics, sensors, and robots; however, such materials are rarely achieved. This work reports a fatigue‐resistant mechanoresponsive color‐changing hydrogel that exhibits reversible, resilient ...
Jiabin Liu   +4 more
wiley   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

open access: yesAdvanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang   +3 more
wiley   +1 more source

Advancements in Carbon‐Based Piezoelectric Materials: Mechanism, Classification, and Applications in Energy Science

open access: yesAdvanced Materials, EarlyView.
Carbon‐based piezoelectric materials are systematically categorized based on their structural and functional properties. The mechanisms of stress‐induced charge transfer are elucidated, and their applications are explored across three key domains: piezoelectric catalysis for energy conversion and environmental remediation, piezoelectric biomedical ...
Mude Zhu   +3 more
wiley   +1 more source

The effect of diabetes on fracture repair : alterations in angiogenesis and apoptosis [PDF]

open access: yes, 2007
Thesis (MSD)--Boston University, Goldman School of Dental Medicine, 2007 (Endodontics).Includes bibliographical references: leaves 56-65.An abundance of evidence has emerged demonstrating a close link between diabetes and significantly impaired fracture ...
Bollman, Megan
core  

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