Results 61 to 70 of about 1,391,337 (356)

Imminent risk of fracture after fracture [PDF]

Osteoporosis International, 2016
The risk of major osteoporotic fracture (MOF) after a first MOF is increased over the whole duration of follow-up, but the imminent risk is even higher. If the acute increment in risk in the few years following MOF is amenable to therapeutic intervention, then immediate short-term treatments may provide worthwhile clinical dividends in a very cost ...
Johansson, H., Siggeirsdóttir, K., Harvey, N.C., Odén, A., Gudnason, V., McCloskey, E., Sigurdsson, G., Kanis, J.A.   +7 more
openaire   +7 more sources

Deep convolutional networks for automated detection of posterior-element fractures on spine CT

, 2016
Injuries of the spine, and its posterior elements in particular, are a common occurrence in trauma patients, with potentially devastating consequences.
Burns, Joseph E., Lu, Le, Roth, Holger R., Summers, Ronald M., Wang, Yinong, Yao, Jianhua   +5 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Open pelvic fracture: the killing fracture? [PDF]

Journal of Orthopaedic Surgery and Research, 2018
Open pelvic fractures are rare but represent a serious clinical problem with high mortality rates. The purpose of this study was to evaluate the outcomes of open pelvic fractures in our clinic and to compare the results from our patient group with those of closed fractures and with the literature from the past decade.Data of patients older than 16 ...
Hermans, E., Edwards, M.J.R., Goslings, J.C., Biert, J.   +3 more
openaire   +5 more sources

Fracture Nasal Bones [PDF]

, 2013
Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face.  Although fractures involving the nasal bones are very common, it is often ignored by the patient.
Thiagarajan, Balasubramanian, Ulaganathan, Venkatesan   +1 more
core   +1 more source

High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes [PDF]

, 2018
Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation.
Carnevale, V., Filardi, Tiziana, Lenzi, A., Massoud, R., Morano, S., Nieddu, L., Romagnoli, E., Russo, C., Tavaglione, F., Turinese, Irene   +9 more
core   +1 more source

Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald, Michela Guglieri, Dragana Vučinić, Gyula Acsadi, John F. Brandsema, Claudio Bruno, Erika L. Finanger, Amy Harper, Mercedes Lopez Lobato, Riccardo Masson, Nuria Muelas, Francina Munell, Yoram Nevo, Yann Péréon, Han Phan, Valeria A. Sansone, Mariacristina Scoto, Tracey Willis, Richard S. Finkel, Krista Vandenborne, Sara Cazzaniga, Silvia Montrasio, Federica Alessi, Paolo Bettica, Eugenio Mercuri, for the Givinostat Study 51 Investigators, the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS) Investigators, the ImagingDMD Investigators, Enrico Bertini, Giacomo Pietro Comi, Eugenio Maria Mercuri, Giuseppe Vita, Sonia Messina, Claudio Bruno, Riccardo Masson, Valeria Sansone, Nathalie Goemans, Liesbeth De Waele, Laurent Servais, Teresa Gidaro, Odile Boespflug‐Tanguy, Yann Péréon, Jessika Johannsen, Astrid Blaschek, Ulrike Schara‐Schmidt, Erik Niks, Imelda de Groot, Saskia Houwen‐van Opstal, Andres Nascimento, Juan Jesus Vilchez, Nuria Muelas, Francina Munell, Marcos Madruga Garrido, Mercedes Lopez Lobato, Michaela Guglieri, Tracey Willis, Stefan Spinty, Daniel Hawcutt, Mariacristina Scoto, Jean K. Mah, Laura McAdam, Kathryn Selby, Katherine Mathews, Craig McDonald, Craig Zaidman, Barry Byrne, John Brandsema, Gyula Acsadi, Chamindra Laverty, Amy Harper, Erika Finanger, Han Phan, Yoram Nevo, Vedrana Milic Rasic, Dragana Vucinic   +74 more
wiley   +1 more source

Hydraulic fracture propagation in naturally fractured reservoirs: Complex fracture or fracture networks [PDF]

Journal of Natural Gas Science and Engineering, 2019
Understanding the behavior of fluid-driven hydraulic fracture in naturally fractured reservoirs is crucial in the development of geothermal energy and unconventional reservoirs. This study presents a fully-coupled numerical model to investigate hydraulic propagation in naturally fractured reservoirs, along with a comprehensive discussion on field ...
openaire   +3 more sources

Fractured meshes

Finite Elements in Analysis and Design, 2023
This work introduces “generalized meshes”, a type of meshes suited for the discretization of partial differential equations in non-regular geometries. Generalized meshes extend regular simplicial meshes by allowing for overlapping elements and more flexible adjacency relations.
Martin Averseng, Xavier Claeys, Ralf Hiptmair   +2 more
openaire   +2 more sources

Transport in rough self-affine fractures

, 2001
Transport properties of three-dimensional self-affine rough fractures are studied by means of an effective-medium analysis and numerical simulations using the Lattice-Boltzmann method.
A.P. Oron, C.Y. Poon, E. Bouchaud, E. Skjetne, F. Plouraboué, F. Plouraboué, F. Plouraboué, G. Dagan, G. Drazer, G. Drazer, G. Drazer, German Drazer, H. Auradou, H.C. Brinkman, J. Boffa, J. Kondev, J. Koplik, J. Koplik, J. Koplik, J. Schmittbuhl, J.B. Walsh, J.C. Bacri, J.M. Luck, J.P. Bouchaud, Joel Koplik, K.H. Coats, L. Durlofsky, M. Sahimi, P. Dijk, P.G. Saffman, P.M. Adler, R. Gutfraind, S. Kirkpatrick, S. Roux, S.R. Brown, S.R. Brown, S.R. Brown, V.V. Mourzenko, W.L. Power, Y. Meheust, Y. Méheust, Y.W. Tsang   +41 more
core   +1 more source