Results 161 to 170 of about 172,523 (297)

Fragile X Mental Retardation Protein in Learning-Related Synaptic Plasticity

Molecules and Cells, 2009
Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein (FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to contribute to synaptic plasticity by regulating plasticity-related protein synthesis and other signaling pathways.
Min Zhuo, Min Zhuo, Valentina Mercaldo, Giannina Descalzi   +3 more
openaire   +3 more sources

A study of the ultrastructure of Fragile-X-related proteins [PDF]

, 2009
Fragile-X-related proteins form a family implicated in RNA metabolism. Their sequence is composed of conserved N-terminal and central regions which contain Tudor and KH domains and of a divergent C-terminus with motifs rich in arginine and glycine ...
Adinolfi, Annalisa Pastore, Ashley, Bagni, Bardoni, Bernado, Brown, Ceman, Darnell, Decatur, De Boulle, De Diego Otero, Dmitri I. Svergun, Dolzhanskaya, Eberhart, Estes, Feng, Garber, Greco, Grishin, Guduric-Fuchs, Guinier, Hagerman, Ian A. Taylor, John Eccleston, Konarev, Lewis, Ljiljana Sjekloća, Lugenbeel, Mazroui, Musco, Pastore, Petoukhov, Petr V. Konarev, Porod, Ramos, Ramos, Ramos, Roessle, Schaeffer, Schuck, Sherman, Siomi, Siomi, Sung, Svergun, Svergun, Svergun, Svergun, Tamanini, Uversky, Valverde, Valverde, Wen, Zalfa, Zhang   +55 more
core   +4 more sources

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Die Rolle von Fragile X Mental Retardation Protein bei der Parkinson-Krankheit [PDF]

, 2020
Recent research suggests α-synuclein (α-Syn)-induced alterations in neuronal excitability contribute to cell death in Parkinson's disease (PD). The Fragile X Mental Retardation Protein (FMRP) controls the expression of numerous genes related to cell ...
Tan, Yi
core  

Reciprocal white matter changes associated with copy number variation at 15q11.2 BP1-BP2: A diffusion tensor imaging study [PDF]

, 2019
Background The 15q11.2 BP1-BP2 cytogenetic region has been associated with learning and motor delays, autism, and schizophrenia. This region includes a gene that codes for the cytoplasmic FMR1 interacting protein 1 (CYFIP1).
Drakesmith, Mark, Gustafsson, Omar, Hall, Jeremy, Linden, David E.J., Owen, Michael J., Silva, Ana I., Stefansson, Hreinn, Stefansson, Kari, Ulfarsson, Magnus O., Walters, G. Bragi, Wilkinson, Lawrence S.   +10 more
core   +2 more sources

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

Nature Communications, 2014
Fragile X syndrome (FXS), the most common heritable form of mental retardation, is characterized by synaptic dysfunction. Synaptic transmission depends critically on presynaptic calcium entry via voltage-gated calcium (CaV) channels.
L. Ferron, M. Nieto-Rostro, J. Cassidy, A. Dolphin   +3 more
semanticscholar   +1 more source

Crucial effect of glass processing and melt homogenization on the fragility of non-stoichiometric chalcogenides [PDF]

, 2013
The kinetics of homogenization of binary As$_x$Se$_{100-x}$ melts in the As concentration range $0\%$ $<$ $x$ $<$ $50\%$ are followed in FT-Raman profiling experiments, and show that 2 gram sized melts in the middle concentration range $20\%$ $<$ $x$ $<$ $30\%$ take nearly two weeks to homogenize when starting materials are reacted at 700$^o$C.
arxiv   +1 more source

Develop machine learning based predictive models for engineering protein solubility [PDF]

arXiv, 2018
Protein activity is a significant characteristic for recombinant proteins which can be used as biocatalysts. High activity of proteins reduces the cost of biocatalysts. A model that can predict protein activity from amino acid sequence is highly desired, as it aids experimental improvement of proteins.
arxiv  

New Targeted Treatments for Fragile X Syndrome [PDF]

, 2019
Fragile X Syndrome (FXS) is the most common cause of inherited intellectual disability with prevalence rates estimated to be 1:5,000 in males and 1:8,000 in females. The increase of \u3e200 Cytosine Guanine Guanine (CGG) repeats in the 5\u27 untranslated
Dy, Jeanne Barbara, Hagerman, Randi J, Potter, Laura A, Protic, Dragana, Salcedo-Arellano, Maria J   +4 more
core   +1 more source