Fragile X Mental Retardation Protein Restricts Small Dye Iontophoresis Entry into Central Neurons. [PDF]
J Neurosci, 2017 Kennedy T, Broadie K.
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Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein. [PDF]
J Comp Neurol, 2017 Sakano H +7 more
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Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse. [PDF]
RNA Biol, 2017 Filippini A +12 more
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Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling. [PDF]
Front Mol Neurosci, 2017 Sears JC, Broadie K.
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The microRNA pathway and fragile X mental retardation protein [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2008 Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP). MicroRNAs (miRNAs), a newly discovered class of small noncoding RNAs, have been implicated in multiple biological processes through posttranscriptional gene regulation.
Peng Jin, Yujing Li
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The role of fragile X mental retardation protein in major mental disorders [PDF]
Neuropharmacology, 2011 Fragile X mental retardation protein (FMRP) is highly enriched in neurons and binds to approximately 4% of mRNAs in mammalian brain. Its loss is a hallmark of fragile X syndrome (FXS), the most common form of mental retardation. In this review we discuss the mutation in the fragile X mental retardation-1 gene (FMR1), that leads to FXS, the role FMRP ...
Timothy D Folsom
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The Fragile X mental retardation protein.
Brain Research Bulletin, 2001The clinical features of the Fragile X mental retardation syndrome are linked to the absence of the set of protein isoforms, derived from alternative splicing of the Fragile X mental retardation gene 1 (FMR1), and collectively termed FMRP. FMRP is an RNA binding protein that is part of a ribonucleoprotein particle associated to actively translating ...
B. Bardoni, A. Schenck, J. Mandel
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Fragile X mental retardation protein in plasticity and disease
Journal of Neuroscience Research, 2002AbstractFragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome ...
Peter K Todd, James S Malter
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Fragile X Mental Retardation Protein in the Driver's Seat [PDF]
Cerebral Cortex, 2009 Fragile X syndrome (FXS), the most common single gene cause of mental retardation, is securely associated with mutations in the fragile X mental retardation 1 gene, FMR1 (Fu et al. 1991; Verkerk et al. 1991; Feng et al. 1997; Musumeci et al. 1999; Hagerman et al. 2009). Nevertheless, identification of consequences of loss of the protein product of FMR1,
Jay E Brenman, Brenman Jay E
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