Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders. [PDF]
Biomol Ther (Seoul), 2017 Jeon SJ, Ryu JH, Bahn GH.
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Fragile X Mental Retardation Protein Restricts Small Dye Iontophoresis Entry into Central Neurons. [PDF]
J Neurosci, 2017 Kennedy T, Broadie K.
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Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein. [PDF]
J Comp Neurol, 2017 Sakano H +7 more
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Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse. [PDF]
RNA Biol, 2017 Filippini A +12 more
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The microRNA pathway and fragile X mental retardation protein [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2008 Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP). MicroRNAs (miRNAs), a newly discovered class of small noncoding RNAs, have been implicated in multiple biological processes through posttranscriptional gene regulation.
Peng Jin, Yujing Li
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The role of fragile X mental retardation protein in major mental disorders [PDF]
Neuropharmacology, 2011 Fragile X mental retardation protein (FMRP) is highly enriched in neurons and binds to approximately 4% of mRNAs in mammalian brain. Its loss is a hallmark of fragile X syndrome (FXS), the most common form of mental retardation. In this review we discuss the mutation in the fragile X mental retardation-1 gene (FMR1), that leads to FXS, the role FMRP ...
, Timothy D Folsom
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On BC1 RNA and the fragile X mental retardation protein [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2008 The fragile X mental retardation protein (FMRP), the functional absence of which causes fragile X syndrome, is an RNA-binding protein that has been implicated in the regulation of local protein synthesis at the synapse. The mechanism of FMRP's interaction with its target mRNAs, however, has remained controversial.
Anna Iacoangeli +2 more
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Fragile X mental retardation protein in plasticity and disease
Journal of Neuroscience Research, 2002AbstractFragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome ...
James S Malter, Peter Todd
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Fragile X Mental Retardation Protein in the Driver's Seat [PDF]
Cerebral Cortex, 2009 Fragile X syndrome (FXS), the most common single gene cause of mental retardation, is securely associated with mutations in the fragile X mental retardation 1 gene, FMR1 (Fu et al. 1991; Verkerk et al. 1991; Feng et al. 1997; Musumeci et al. 1999; Hagerman et al. 2009). Nevertheless, identification of consequences of loss of the protein product of FMR1,
Brenman Jay E, Jay E Brenman
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The Fragile X mental retardation protein
Brain Research Bulletin, 2001The clinical features of the Fragile X mental retardation syndrome are linked to the absence of the set of protein isoforms, derived from alternative splicing of the Fragile X mental retardation gene 1 (FMR1), and collectively termed FMRP. FMRP is an RNA binding protein that is part of a ribonucleoprotein particle associated to actively translating ...
Bardoni, Barbara +2 more
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