Results 111 to 120 of about 11,078,474 (189)

Circadian rhythm-dependent alterations of gene expression in Drosophila brain lacking fragile X mental retardation protein.

, 2012
Fragile X syndrome is caused by the loss of the FMR1 gene product, fragile X mental retardation protein (FMRP). The loss of FMRP leads to altered circadian rhythm behaviors in both mouse and Drosophila; however, the molecular mechanism behind this ...
Bi Jianzhong, Shunliang Xu, Mickael Poidevin, Jianzhong Bi, Poidevin Mickael, Han Enji, Enji Han, Xu Shunliang, Jin Peng, Peng Jin   +9 more
core   +1 more source

Fragile X Mental Retardation Protein: Nucleocytoplasmic Shuttling and Association with Somatodendritic Ribosomes

, 1997
Fragile X syndrome, a leading cause of inherited mental retardation, is attributable to the unstable expansion of a CGG-repeat within the FMR1 gene that results in the absence of the encoded protein.
Yue Feng, Derek E. Eberhart, Stephen T. Warren, Steven M. Hersch, Hong Yi, Claire-Anne Gutekunst   +5 more
core   +1 more source

A mouse model of the human Fragile X syndrome I304N mutation.

PLoS Genetics, 2009
The mental retardation, autistic features, and behavioral abnormalities characteristic of the Fragile X mental retardation syndrome result from the loss of function of the RNA-binding protein FMRP.
Julie B Zang, Elena D Nosyreva, Corinne M Spencer, Lenora J Volk, Kiran Musunuru, Ru Zhong, Elizabeth F Stone, Lisa A Yuva-Paylor, Kimberly M Huber, Richard Paylor, Jennifer C Darnell, Robert B Darnell   +11 more
doaj   +1 more source

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Frontiers in Aging Neuroscience, 2017
Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing
Roman Smidak, Fernando J. Sialana, Martina Kristofova, Tamara Stojanovic, Dragana Rajcic, Jovana Malikovic, Daniel D. Feyissa, Volker Korz, Harald Hoeger, Judit Wackerlig, Diana Mechtcheriakova, Gert Lubec, Gert Lubec   +12 more
doaj   +1 more source

BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Neurobiology of Disease, 2002
Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions. We have investigated whether FMRP and BDNF are reciprocally regulated in neurons.
Castren, ML, Lampinen, KE, Miettinen, R, Koponen, E, Sipola, I, Bakker, CE, Oostra, Ben, Castren, E   +7 more
openaire   +4 more sources

The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis. [PDF]

Cell Mol Gastroenterol Hepatol, 2021
Di Grazia A, Marafini I, Pedini G, Di Fusco D, Laudisi F, Dinallo V, Rosina E, Stolfi C, Franzè E, Sileri P, Sica G, Monteleone G, Bagni C, Monteleone I.   +13 more
europepmc   +1 more source

Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge. [PDF]

Oncogene, 2021
Carotti S, Zingariello M, Francesconi M, D'Andrea L, Latasa MU, Colyn L, Fernandez-Barrena MG, Flammia RS, Falchi M, Righi D, Pedini G, Pantano F, Bagni C, Perrone G, Rana RA, Avila MA, Morini S, Zalfa F.   +17 more
europepmc   +1 more source

Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity. [PDF]

Mol Ther Methods Clin Dev, 2021
Hooper AWM, Wong H, Niibori Y, Abdoli R, Karumuthil-Melethil S, Qiao C, Danos O, Bruder JT, Hampson DR.   +8 more
europepmc   +1 more source

Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a. [PDF]

Front Cell Neurosci, 2022
Chen H, Qiao D, Wang C, Zhang B, Wang Z, Tang L, Wang Y, Zhang R, Zhang Y, Song L, Zuo H, Guo F, Wang X, Li S, Cui H.   +14 more
europepmc   +1 more source

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density. [PDF]

, 2014
Fragile X syndrome (FXS), the most common heritable form of mental retardation, is characterized by synaptic dysfunction. Synaptic transmission depends critically on presynaptic calcium entry via voltage-gated calcium (CaV) channels.
Ferron, L, Dolphin, AC, Cassidy, JS, Nieto-Rostro, M   +3 more
core