Results 111 to 120 of about 21,934 (176)

Fragile X Mental Retardation Protein Requirements in Activity-Dependent Critical Period Neural Circuit Refinement

Current Biology, 2017
Summary Activity-dependent synaptic remodeling occurs during early-use critical periods, when naïve juveniles experience sensory input. Fragile X Mental Retardation Protein (FMRP) sculpts synaptic refinement in an activity sensor mechanism based on ...
Caleb A. Doll, Dominic J. Vita, K. Broadie   +2 more
semanticscholar   +1 more source

A mouse model of the human Fragile X syndrome I304N mutation.

PLoS Genetics, 2009
The mental retardation, autistic features, and behavioral abnormalities characteristic of the Fragile X mental retardation syndrome result from the loss of function of the RNA-binding protein FMRP.
Julie B Zang, Elena D Nosyreva, Corinne M Spencer, Lenora J Volk, Kiran Musunuru, Ru Zhong, Elizabeth F Stone, Lisa A Yuva-Paylor, Kimberly M Huber, Richard Paylor, Jennifer C Darnell, Robert B Darnell   +11 more
doaj   +1 more source

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Frontiers in Aging Neuroscience, 2017
Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing
Roman Smidak, Fernando J. Sialana, Martina Kristofova, Tamara Stojanovic, Dragana Rajcic, Jovana Malikovic, Daniel D. Feyissa, Volker Korz, Harald Hoeger, Judit Wackerlig, Diana Mechtcheriakova, Gert Lubec, Gert Lubec   +12 more
doaj   +1 more source

BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Neurobiology of Disease, 2002
Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions. We have investigated whether FMRP and BDNF are reciprocally regulated in neurons.
Castren, ML, Lampinen, KE, Miettinen, R, Koponen, E, Sipola, I, Bakker, CE, Oostra, Ben, Castren, E   +7 more
openaire   +4 more sources

Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge. [PDF]

Oncogene, 2021
Carotti S, Zingariello M, Francesconi M, D'Andrea L, Latasa MU, Colyn L, Fernandez-Barrena MG, Flammia RS, Falchi M, Righi D, Pedini G, Pantano F, Bagni C, Perrone G, Rana RA, Avila MA, Morini S, Zalfa F.   +17 more
europepmc   +1 more source

Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a. [PDF]

Front Cell Neurosci, 2022
Chen H, Qiao D, Wang C, Zhang B, Wang Z, Tang L, Wang Y, Zhang R, Zhang Y, Song L, Zuo H, Guo F, Wang X, Li S, Cui H.   +14 more
europepmc   +1 more source

Increased expression of Fragile X mental retardation protein in malformative lesions of patients with focal cortical dysplasia. [PDF]

Neuroreport, 2020
Reynolds CD, Nolan SO, Smith GD, Jefferson TS, Hodges SL, Brewster AL, Lugo JN.   +6 more
europepmc   +1 more source

Progress in the study on pathogenic mechanism of fragile X mental retardation protein

Chinese Journal of Contemporary Neurology and Neurosurgery, 2010
DOI：10.3969/j.issn.1672-6731.2010.03 ...
Yu⁃xia DONG, Xiao⁃hong SUN, Wei⁃ke SONG, et al   +3 more
doaj  

Correction: Differential regulation of BK channels by fragile X mental retardation protein. [PDF]

J Gen Physiol, 2020
Kshatri A, Cerrada A, Gimeno R, Bartolomé-Martín D, Rojas P, Giraldez T.   +5 more
europepmc   +1 more source

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation.

Proceedings of the National Academy of Sciences of the United States of America, 1997
I. Weiler, Scott A. Irwin, A. Klintsova, C. Spencer, Anthony D. Brazelton, K. Miyashiro, T. Comery, B. Patel, J. Eberwine, W. Greenough   +9 more
semanticscholar   +1 more source