Results 91 to 100 of about 16,335 (162)

Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study. [PDF]

Brain Sci, 2022
Brašić JR, Goodman JA, Nandi A, Russell DS, Jennings D, Barret O, Martin SD, Slifer K, Sedlak T, Mathur AK, Seibyl JP, Berry-Kravis EM, Wong DF, Budimirovic DB.   +13 more
europepmc   +1 more source

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

Annals of Neurology, 2007
AbstractObjectiveTo determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation‐1 protein and to aberrant cognition and behavior.MethodsThis study included 84 children and adolescents with the fragile X full mutation and 72 typically developing control ...
Doron, Gothelf, Joyce A, Furfaro, Fumiko, Hoeft, Mark A, Eckert, Scott S, Hall, Ruth, O'Hara, Heather W, Erba, Jessica, Ringel, Kiralee M, Hayashi, Swetapadma, Patnaik, Brenda, Golianu, Helena C, Kraemer, Paul M, Thompson, Joseph, Piven, Allan L, Reiss   +14 more
openaire   +3 more sources

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

A mouse model of the human Fragile X syndrome I304N mutation.

PLoS Genetics, 2009
The mental retardation, autistic features, and behavioral abnormalities characteristic of the Fragile X mental retardation syndrome result from the loss of function of the RNA-binding protein FMRP.
Julie B Zang, Elena D Nosyreva, Corinne M Spencer, Lenora J Volk, Kiran Musunuru, Ru Zhong, Elizabeth F Stone, Lisa A Yuva-Paylor, Kimberly M Huber, Richard Paylor, Jennifer C Darnell, Robert B Darnell   +11 more
doaj   +1 more source

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Frontiers in Aging Neuroscience, 2017
Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing
Roman Smidak, Fernando J. Sialana, Martina Kristofova, Tamara Stojanovic, Dragana Rajcic, Jovana Malikovic, Daniel D. Feyissa, Volker Korz, Harald Hoeger, Judit Wackerlig, Diana Mechtcheriakova, Gert Lubec, Gert Lubec   +12 more
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BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Neurobiology of Disease, 2002
Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions. We have investigated whether FMRP and BDNF are reciprocally regulated in neurons.
Castren, ML, Lampinen, KE, Miettinen, R, Koponen, E, Sipola, I, Bakker, CE, Oostra, Ben, Castren, E   +7 more
openaire   +4 more sources

The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis. [PDF]

Cell Mol Gastroenterol Hepatol, 2021
Di Grazia A, Marafini I, Pedini G, Di Fusco D, Laudisi F, Dinallo V, Rosina E, Stolfi C, Franzè E, Sileri P, Sica G, Monteleone G, Bagni C, Monteleone I.   +13 more
europepmc   +1 more source

Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge. [PDF]

Oncogene, 2021
Carotti S, Zingariello M, Francesconi M, D'Andrea L, Latasa MU, Colyn L, Fernandez-Barrena MG, Flammia RS, Falchi M, Righi D, Pedini G, Pantano F, Bagni C, Perrone G, Rana RA, Avila MA, Morini S, Zalfa F.   +17 more
europepmc   +1 more source

Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity. [PDF]

Mol Ther Methods Clin Dev, 2021
Hooper AWM, Wong H, Niibori Y, Abdoli R, Karumuthil-Melethil S, Qiao C, Danos O, Bruder JT, Hampson DR.   +8 more
europepmc   +1 more source

Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a. [PDF]

Front Cell Neurosci, 2022
Chen H, Qiao D, Wang C, Zhang B, Wang Z, Tang L, Wang Y, Zhang R, Zhang Y, Song L, Zuo H, Guo F, Wang X, Li S, Cui H.   +14 more
europepmc   +1 more source