Results 81 to 90 of about 16,335 (162)
Developmental Medicine &Child Neurology, Volume 68, Issue 7, Page 909-915, July 2026.Abstract After treatment with new disease‐modifying therapies, cognitive and neurodevelopmental aspects have been observed in individuals with spinal muscular atrophy (SMA). Emerging evidence suggests that children with SMA type 1 may experience cognitive, language, and behavioural delays, with reported rates of neurodevelopmental difficulties ranging ...
Giorgia Coratti +2 more
wiley +1 more source
Clinical Development of Targeted Fragile X Syndrome Treatments: An Industry Perspective
Brain Sciences, 2018 Fragile X syndrome (FXS) is the leading known cause of inherited intellectual disability and autism spectrum disorder. It is caused by a mutation of the fragile X mental retardation 1 (FMR1) gene, resulting in a deficit of fragile X mental retardation ...
Anna W. Lee +4 more
doaj +1 more source
Fragile X Mental Retardation Protein in Learning-Related Synaptic Plasticity
Molecules and Cells, 2009 Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein (FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to contribute to synaptic plasticity by regulating plasticity-related protein synthesis and other signaling pathways.
Valentina, Mercaldo +2 more
openaire +2 more sources
Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn. [PDF]
J Comp Neurol, 2023 Mitchell ME +6 more
europepmc +1 more source
Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons. [PDF]
Proc Natl Acad Sci U S A, 2023 Song C, Broadie K.
europepmc +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
BMC Genetics, 2000 Background The family of Fragile X Mental Retardation Proteins is composed of three members: Fragile Mental Retardation 1, Fragile X Related 1 and X Related 2 proteins.
Khandjian Edouard W +2 more
doaj +1 more source
Cellular distribution of the Fragile X mental retardation protein in the inner ear: a developmental and comparative study in the mouse, rat, gerbil, and chicken. [PDF]
J Comp Neurol, 2023 Wang X, Fan Q, Yu X, Wang Y.
europepmc +1 more source
PLoS ONE, 2010 BackgroundExpansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1, fragile X mental retardation 1, gene results in suppression of protein expression for this gene and is the underlying cause of Fragile X syndrome.
Melanie A Adams-Cioaba +8 more
doaj +1 more source
Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome
Neurobiology of Disease, 2009 The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors.
Topi A. Tervonen +7 more
doaj +1 more source