Results 61 to 70 of about 21,934 (176)
Annals of Neurology, 2008 AbstractObjectiveTo determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation‐1 protein and to aberrant cognition and behavior.MethodsThis study included 84 children and adolescents with the fragile X full mutation and 72 typically developing control ...
D. Gothelf +14 more
semanticscholar +4 more sources
Hair root FMRP expression for screening of fragile X full mutation females
Universa Medicina, 2016 The fragile X syndrome is the most common form of inherited mental retardation in humans, caused by an expansion of the cytosine-guanine-guanine (CGG) repeat in the fragile X mental retardation 1 (FMR1) gene located on the X chromosome.
Lantip Rujito +5 more
doaj +1 more source
Fragile X Mental Retardation Protein FMRP Binds mRNAs in the Nucleus [PDF]
Molecular and Cellular Biology, 2009 The fragile X mental retardation protein FMRP is an RNA binding protein that associates with a large collection of mRNAs. Since FMRP was previously shown to be a nucleocytoplasmic shuttling protein, we examined the hypothesis that FMRP binds its cargo mRNAs in the nucleus.
Miri, Kim +2 more
openaire +2 more sources
PLoS Genetics, 2015 Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot +10 more
doaj +1 more source
Detection and Quantification of the Fragile X Mental Retardation Protein 1 (FMRP). [PDF]
Genes (Basel), 2016 The final product of FMR1 gene transcription, Fragile X Mental Retardation Protein 1 (FMRP), is an RNA binding protein that acts as a repressor of translation. FMRP is expressed in several tissues and plays important roles in neurogenesis, synaptic plasticity, and ovarian functions and has been implicated in a number of neuropsychological disorders ...
LaFauci G +3 more
europepmc +4 more sources
The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation [PDF]
Molecular Neurobiology, 2009 The control of new protein synthesis provides a means to locally regulate the availability of synaptic components necessary for dynamic neuronal processes. The fragile X mental retardation protein (FMRP), an RNA-binding translational regulator, is a key player mediating appropriate synaptic protein synthesis in response to neuronal activity levels ...
Cheryl L, Gatto, Kendal, Broadie
openaire +2 more sources
PLoS Genetics, 2009 Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays
Yingyue Yang +6 more
doaj +1 more source
PLoS Genetics, 2016 Local translation at the synapse plays key roles in neuron development and activity-dependent synaptic plasticity. mRNAs are translocated from the neuronal soma to the distant synapses as compacted ribonucleoparticles referred to as RNA granules.
Rachid El Fatimy +7 more
semanticscholar +1 more source
The research progress on the role of FMRP in the pathogenesis of tumors
Pifu-xingbing zhenliaoxue zazhi, 2023 Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions.
Huizhi YANG +5 more
doaj +1 more source
Genes & Development, 2005 Fragile-X mental retardation is caused by loss of function of a single gene encoding the Fragile-X mental retardation protein, FMRP, an RNA-binding protein that harbors two KH-type and one RGG-type RNA-binding domains.
J. Darnell +6 more
semanticscholar +1 more source