Results 51 to 60 of about 21,934 (176)
Nature Neuroscience, 2007 Fragile X syndrome (FXS) results from the loss of the fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates a variety of cytoplasmic mRNAs.
F. Zalfa +10 more
semanticscholar +1 more source
A nuclear role for the Fragile X mental retardation protein. [PDF]
The EMBO Journal, 1996 Fragile X syndrome results from lack of expression of a functional form of Fragile X mental retardation protein (FMRP), a cytoplasmic RNA-binding protein of uncertain function. Here, we report that FMRP contains a nuclear export signal (NES) that is similar to the NES recently identified in the Rev regulatory protein of human immunodeficiency virus ...
R A, Fridell +4 more
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Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome
Molecules and Cells, 2014 Summary Fragile X syndrome (FXS) is the most common form of inherited mental retardation and it is caused by loss of function of the Fragile X Mental Retardation Protein (FMRP).
E. Chen +4 more
semanticscholar +1 more source
Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila
Disease Models & Mechanisms, 2013 SUMMARY Fragile X syndrome (FXS), the most common inherited determinant of intellectual disability and autism spectrum disorders, is caused by loss of the fragile X mental retardation 1 (FMR1) gene product (FMRP), an mRNA-binding translational repressor.
Samuel H. Friedman +3 more
doaj +1 more source
The Drosophila fragile X mental retardation protein participates in the piRNA pathway [PDF]
Journal of Cell Science, 2015 ABSTRACT RNA metabolism controls multiple biological processes, and a specific class of small RNAs, called piRNAs, act as genome guardians by silencing the expression of transposons and repetitive sequences in the gonads. Defects in the piRNA pathway affect genome integrity and fertility.
Bozzetti, Maria Pia +11 more
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Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
Nature Neuroscience, 2010 In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability.
Maile R. Brown +7 more
semanticscholar +1 more source
Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus [PDF]
Learning & Memory, 2011 Silencing of a single gene, FMR1, is linked to a highly prevalent form of mental retardation, characterized by social and cognitive impairments, known as fragile X syndrome (FXS). The FMR1 gene encodes fragile X mental retardation protein (FMRP), which negatively regulates translation.
Steven A, Connor +3 more
openaire +2 more sources
PLoS ONE, 2012 Fragile X syndrome (FXS) is a well-recognized form of inherited mental retardation, caused by a mutation in the fragile X mental retardation 1 (Fmr1) gene.
Snigdha Roy, Nick Watkins, Detlef Heck
doaj +1 more source
Journal of Neuroscience, 2004 Fragile X syndrome is caused by the absence of the mRNA-binding protein Fragile X mental retardation protein (FMRP), which may play a role in activity-regulated localization and translation of mRNA in dendrites and at synapses.
L. Antar +4 more
semanticscholar +1 more source
Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
Nature Communications, 2018 Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by ...
Yue Li +9 more
doaj +1 more source