Results 71 to 80 of about 16,335 (162)

FMR1: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment

Biomolecules
The Fragile X Mental Retardation 1 (FMR1) gene is well-known for its role in Fragile X syndrome, a neurodevelopmental disorder, but emerging evidence suggests its involvement in regulating cellular metabolism, with implications for cancer biology.
Renbin Zhou, Hao Lin, Xinyu Dou, Bang Zeng, Xinyi Zhao, Lei Ma, Drissa Diarra, Bing Liu, Wei-Wei Deng, Tianfu Wu   +9 more
doaj   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

Cerebral Protein Synthesis in a Knockin Mouse Model of the Fragile X Premutation

ASN Neuro, 2014
The (CGG)n-repeat in the 5′-untranslated region of the fragile X mental retardation gene ( FMR1 ) gene is polymorphic and may become unstable on transmission to the next generation.
Mei Qin, Tianjian Huang, Zhonghua Liu, Michael Kader, Thomas Burlin, Zengyan Xia, Zachary Zeidler, Renate K. Hukema, Carolyn B. Smith   +8 more
doaj   +1 more source

Clinical, molecular, and pharmacological aspects of FMR1-related disorders

Neurología (English Edition), 2017
Background: Fragile X syndrome, the most common inherited cause of intellectual disability, is associated with a broad spectrum of disorders across different generations of a single family.
A. Pugin, V. Faundes, L. Santa María, B. Curotto, S. Aliaga, I. Salas, P. Soto, P. Bravo, M.I. Peña, M.A. Alliende   +9 more
doaj   +1 more source

Aspectos clínicos, moleculares y farmacológicos en los trastornos asociados a gen 1 del retraso mental del X frágil

Neurología, 2017
Resumen: Introducción: El síndrome X frágil (SXF) es la causa más frecuente de discapacidad intelectual hereditaria y se asocia a un amplio espectro de enfermedades en las distintas generaciones de una misma familia.
A. Pugin, V. Faundes, L. Santa María, B. Curotto, S. Aliaga, I. Salas, P. Soto, P. Bravo, M.I. Peña, M.A. Alliende   +9 more
doaj   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Expression profiling suggests underexpression of the GABAA receptor subunit δ in the fragile X knockout mouse model

Neurobiology of Disease, 2006
It is still unclear why absence of the fragile X protein (FMRP) leads to mental retardation and specific behavioral problems. In neurons, the protein transports specific mRNAs towards the actively translating ribosomes near the synapses.To unravel the ...
Ilse Gantois, Jo Vandesompele, Frank Speleman, Edwin Reyniers, Rudi D'Hooge, Lies-Anne Severijnen, Rob Willemsen, Flora Tassone, R. Frank Kooy   +8 more
doaj   +1 more source

The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies

American Journal of Reproductive Immunology, Volume 96, Issue 1, July 2026.
ABSTRACT Sex hormones and reproductive transitions profoundly shape immune, metabolic, neuropsychological, and mucosal biology, as well as HIV persistence, across women's lives. Although women constitute the majority of people with HIV worldwide, hormonal and reproductive biology are still not sufficiently incorporated into HIV cure research. Cisgender
Elizabeth Hastie, Priya Khetan, Sarah A. LaMere, Ashley F. George, Rebecca Abelman, Kathleen Weber, Phyllis C. Tien, Judith D. Auerbach, Maile Karris, Todd Brown, Jonathan Karn, Loreen Willenberg, Dawn Averitt, Bridgette Picou, Nadia R. Roan, Eileen P. Scully, Karine Dubé, Nancie Archin, Sara Gianella   +18 more
wiley   +1 more source

Characterization of Fragile X Mental Retardation Protein granules formation and dynamics in Drosophila

Biology Open, 2012
Summary FMRP is an evolutionarily conserved protein that is highly expressed in neurons and its deficiency causes fragile X mental retardation syndrome.
Cristina Gareau, David Martel, Laetitia Coudert, Samia Mellaoui, Rachid Mazroui   +4 more
doaj   +1 more source

Fragile X Syndrome and Targeted Treatments

Journal of Biomedicine and Translational Research, 2020
Many targeted treatment studies have been carried out in individuals with Fragile X Syndrome (FXS) guided by animal studies from the Fragile X Mental Retardation 1 (FMR1) knock out (KO) mice and the fragile X Drosophila studies.
Nattaporn Tassanakijpanich, Ana María Cabal-Herrera, Maria Jimena Salcedo-Arellano, Randi Jenssen Hagerman   +3 more
doaj   +1 more source