Results 101 to 110 of about 21,934 (176)

Age-Dependent and Selective Impairment of Long-Term Potentiation in the Anterior Piriform Cortex of Mice Lacking the Fragile X Mental Retardation Protein

Journal of Neuroscience, 2005
Synaptic function and plasticity were studied in mice lacking the fragile X mental retardation protein (FMRP), a model for the fragile X mental retardation syndrome. Associational connections were studied in slices of anterior piriform (olfactory) cortex,
J. Larson, Ruth E. Jessen, Daniel Kim, A. Fine, Johann du Hoffmann   +4 more
semanticscholar   +1 more source

Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons. [PDF]

Proc Natl Acad Sci U S A, 2023
Song C, Broadie K.
europepmc   +1 more source

Cellular distribution of the Fragile X mental retardation protein in the inner ear: a developmental and comparative study in the mouse, rat, gerbil, and chicken. [PDF]

J Comp Neurol, 2023
Wang X, Fan Q, Yu X, Wang Y.
europepmc   +1 more source

Muscle Specific Fragile X Related Protein 1 Isoforms are Sequestered in the Nucleus of Undifferentiated Myoblast

BMC Genetics, 2000
Background The family of Fragile X Mental Retardation Proteins is composed of three members: Fragile Mental Retardation 1, Fragile X Related 1 and X Related 2 proteins.
Khandjian Edouard W, Huot Marc-Etienne, Dubé Marthe   +2 more
doaj   +1 more source

Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study. [PDF]

Brain Sci, 2022
Brašić JR, Goodman JA, Nandi A, Russell DS, Jennings D, Barret O, Martin SD, Slifer K, Sedlak T, Mathur AK, Seibyl JP, Berry-Kravis EM, Wong DF, Budimirovic DB.   +13 more
europepmc   +1 more source

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

Nature Communications, 2014
Fragile X syndrome (FXS), the most common heritable form of mental retardation, is characterized by synaptic dysfunction. Synaptic transmission depends critically on presynaptic calcium entry via voltage-gated calcium (CaV) channels.
L. Ferron, M. Nieto-Rostro, J. Cassidy, A. Dolphin   +3 more
semanticscholar   +1 more source

Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.

PLoS ONE, 2010
BackgroundExpansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1, fragile X mental retardation 1, gene results in suppression of protein expression for this gene and is the underlying cause of Fragile X syndrome.
Melanie A Adams-Cioaba, Yahong Guo, ChuanBing Bian, Maria F Amaya, Robert Lam, Gregory A Wasney, Masoud Vedadi, Chao Xu, Jinrong Min   +8 more
doaj   +1 more source

Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome

Neurobiology of Disease, 2009
The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors.
Topi A. Tervonen, Verna Louhivuori, Xiaohong Sun, Marie-Estelle Hokkanen, Claudius F. Kratochwil, Pawel Zebryk, Eero Castrén, Maija L. Castrén   +7 more
doaj   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

Bidirectional Regulation of Dendritic Voltage-gated Potassium Channels by the Fragile X Mental Retardation Protein

Neuron, 2011
Summary How transmitter receptors modulate neuronal signaling by regulating voltage-gated ion channel expression remains an open question. Here we report dendritic localization of mRNA of Kv4.2 voltage-gated potassium channel, which regulates synaptic ...
Hye Young Lee, Woo-ping Ge, Wendy C. Huang, Ye He, Gordon X. Wang, Ashley Rowson-Baldwin, Stephen J. Smith, Y. Jan, L. Jan   +8 more
semanticscholar   +1 more source