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Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse. [PDF]
RNA Biol, 2017 Filippini A +12 more
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The microRNA pathway and fragile X mental retardation protein [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2008 Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP). MicroRNAs (miRNAs), a newly discovered class of small noncoding RNAs, have been implicated in multiple biological processes through posttranscriptional gene regulation.
Peng Jin, Yujing Li
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The role of fragile X mental retardation protein in major mental disorders [PDF]
Neuropharmacology, 2011 Fragile X mental retardation protein (FMRP) is highly enriched in neurons and binds to approximately 4% of mRNAs in mammalian brain. Its loss is a hallmark of fragile X syndrome (FXS), the most common form of mental retardation. In this review we discuss the mutation in the fragile X mental retardation-1 gene (FMR1), that leads to FXS, the role FMRP ...
Timothy D Folsom
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Fragile X mental retardation protein in plasticity and disease
Journal of Neuroscience Research, 2002AbstractFragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome ...
James S Malter, Peter K Todd
exaly +3 more sources
Fragile X mental retardation protein in the driver's seat. [PDF]
Cerebral Cortex, 2009 Fragile X syndrome (FXS), the most common single gene cause of mental retardation, is securely associated with mutations in the fragile X mental retardation 1 gene, FMR1 (Fu et al. 1991; Verkerk et al. 1991; Feng et al. 1997; Musumeci et al. 1999; Hagerman et al. 2009). Nevertheless, identification of consequences of loss of the protein product of FMR1,
Jay E Brenman
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Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins [PDF]
Biochimie, 2015 Translational control is a common mechanism used to regulate gene expression and occur in bacteria to mammals. Typically in translational control, an RNA-binding protein binds to a unique sequence in the mRNA to regulate protein synthesis by the ...
Simpson Joseph
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The fragile X mental retardation protein is associated with ribosomes
Nature Genetics, 1996Fragile X mental retardation syndrome is one of the most common human genetic diseases. Patients carry a methylated expansion of a CGG repeat resulting in the silencing of the FMR1 gene1–5 that codes for a heterogeneous set of proteins (FMRP)6–9. FMRP is abundant in neurons and is also widely expressed, albeit at different levels, in various human and ...
E W, Khandjian +3 more
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Fragile X Mental Retardation Protein and Stem Cells
2011Stem cells, which can self-renew and produce different cell types, are regulated by both extrinsic signals and intrinsic factors. Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP).
Abrar, Qurashi, Xuekun, Li, Peng, Jin
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Fragile X Mental Retardation Protein: Past, Present and Future
Current Protein & Peptide Science, 2012We begin by reviewing the first characterization of fragile X syndrome, which ultimately led to cloning of the FMR1 gene. Discovery of the molecular basis of this disorder, including expansion of a trinucleotide repeat, gave insight not only into fragile X syndrome but also into the premutation syndromes.
Miri, Kim, Stephanie, Ceman
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Manipulating the Fragile X Mental Retardation Proteins in the Frog
2011The frog is a model of choice to study gene function during early development, since a large number of eggs are easily obtained and rapidly develop external to the mother. This makes it a highly flexible model system in which direct tests of gene function can be investigated by microinjecting RNA antisense reagents. Two members of the Fragile X Related
Marc-Etienne, Huot +3 more
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