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Fragile X Mental Retardation Protein expression in the retina is regulated by light. [PDF]
Exp Eye Res, 2016 Guimarães-Souza EM +4 more
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Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling. [PDF]
Front Mol Neurosci, 2017 Sears JC, Broadie K.
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The Fragile X mental retardation protein
Brain Research Bulletin, 2001The clinical features of the Fragile X mental retardation syndrome are linked to the absence of the set of protein isoforms, derived from alternative splicing of the Fragile X mental retardation gene 1 (FMR1), and collectively termed FMRP. FMRP is an RNA binding protein that is part of a ribonucleoprotein particle associated to actively translating ...
Bardoni, Barbara +2 more
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Fragile X mental retardation protein in plasticity and disease
Journal of Neuroscience Research, 2002AbstractFragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome ...
Peter K, Todd, James S, Malter
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Fragile X Mental Retardation Protein: Past, Present and Future
Current Protein & Peptide Science, 2012We begin by reviewing the first characterization of fragile X syndrome, which ultimately led to cloning of the FMR1 gene. Discovery of the molecular basis of this disorder, including expansion of a trinucleotide repeat, gave insight not only into fragile X syndrome but also into the premutation syndromes.
Miri, Kim, Stephanie, Ceman
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Fragile X Mental Retardation Protein and Stem Cells
2011Stem cells, which can self-renew and produce different cell types, are regulated by both extrinsic signals and intrinsic factors. Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP).
Abrar, Qurashi, Xuekun, Li, Peng, Jin
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The fragile X mental retardation protein, FMRP, recognizes G‐quartets
Mental Retardation and Developmental Disabilities Research Reviews, 2004AbstractFragile X mental retardation is a disease caused by the loss of function of a single RNA‐binding protein, FMRP. Identifying the RNA targets recognized by FMRP is likely to reveal much about its functions in controlling some aspects of memory and behavior.
Jennifer C, Darnell +2 more
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The fragile X mental retardation protein is associated with ribosomes
Nature Genetics, 1996Fragile X mental retardation syndrome is one of the most common human genetic diseases. Patients carry a methylated expansion of a CGG repeat resulting in the silencing of the FMR1 gene1–5 that codes for a heterogeneous set of proteins (FMRP)6–9. FMRP is abundant in neurons and is also widely expressed, albeit at different levels, in various human and ...
E W, Khandjian +3 more
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Manipulating the Fragile X Mental Retardation Proteins in the Frog
2011The frog is a model of choice to study gene function during early development, since a large number of eggs are easily obtained and rapidly develop external to the mother. This makes it a highly flexible model system in which direct tests of gene function can be investigated by microinjecting RNA antisense reagents. Two members of the Fragile X Related
Marc-Etienne, Huot +3 more
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Structure-Function Analysis of Axonal Fragile X Mental Retardation Protein
2021Silencing of the Fragile X Mental Retardation Protein (FMRP)-encoding gene Fmr1 causes Fragile X Syndrome, the leading known cause of autism. FMRP is an alternatively spliced, multidomain, RNA-binding protein most highly expressed in the brain that regulates mRNA transport and translation.
Stephanie Elaine Zimmer +1 more
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