Results 181 to 190 of about 172,523 (297)

Genome wide identification of regulatory networks associated with general cognitive ability using a normalized alignment free similarity measure of promoter regions [PDF]

arXiv, 2013
We show that a normalized alignment free similarity measure, called D2z, can be used to detect potential regulatory relations for gene sets when little is known about the regulatory elements involved. One scenario where such gene sets arise is genome wide association studies (GWAS).
arxiv  

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities*

Journal of Biological Chemistry, 2009
Functional absence of fragile X mental retardation protein (FMRP) causes the fragile X syndrome, a hereditary form of mental retardation characterized by a change in dendritic spine morphology.
Janin Schütt, K. Falley, D. Richter, H. Kreienkamp, S. Kindler   +4 more
semanticscholar   +1 more source

Retardation of Bulk Water Dynamics by Disaccharide Osmolytes [PDF]

arXiv, 2016
The bioprotective nature of disaccharides is hypothesized to derive from the modification of the hydrogen bonding network of water which protects biomolecules through lowered water activity at the protein interface. Using ultrafast fluorescence spectroscopy we measured the relaxation of bulk water dynamics around the induced dipole moment of two ...
arxiv  

History Tends to Repeat: FMR-1 Silencing in Fragile X Syndrome [PDF]

Fragile X syndrome is the most common form of inherited mental retardation, and afflicts 1 in 1250 males and 1 in 2500 females. The symptoms include connective tissue displasia, mental retardation, and macroorchidism (enlarged testis).
Haas, Joshua
core   +1 more source

Age-Dependent and Selective Impairment of Long-Term Potentiation in the Anterior Piriform Cortex of Mice Lacking the Fragile X Mental Retardation Protein

Journal of Neuroscience, 2005
Synaptic function and plasticity were studied in mice lacking the fragile X mental retardation protein (FMRP), a model for the fragile X mental retardation syndrome. Associational connections were studied in slices of anterior piriform (olfactory) cortex,
J. Larson, Ruth E. Jessen, Daniel Kim, A. Fine, Johann du Hoffmann   +4 more
semanticscholar   +1 more source

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Frontiers in Aging Neuroscience, 2017
Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing
Roman Smidak, Fernando J. Sialana, Martina Kristofova, Tamara Stojanovic, Dragana Rajcic, Jovana Malikovic, Daniel D. Feyissa, Volker Korz, Harald Hoeger, Judit Wackerlig, Diana Mechtcheriakova, Gert Lubec, Gert Lubec   +12 more
doaj   +1 more source

The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.

Human Molecular Genetics, 1996
Fragile X syndrome is a frequent cause of mental retardation resulting from the absence of FMRP, the protein encoded by the FMR1 gene. FMRP is an RNA-binding protein of unknown function which is associated with ribosomes.
D. Eberhart, H. Malter, Yue Feng, S. Warren   +3 more
semanticscholar   +1 more source

The translational regulator dFMRP interacts with epidermal growth factor receptor to regulate apoptosis in Drosophila [PDF]

, 2016
poster abstractPosttranscriptional gene regulation is required for all aspects of cellular and tissue development and is a major mechanism underlying many diseases ranging from neurological disorders to cancer.
Sherwood, Jacqueline E., Tessier, Charles R., Zic, Jessica Z.   +2 more
core  

Global Estimates and Regularity of Retarded Parabolic Equations with Fast-growing Nonlinearities [PDF]

arXiv, 2019
This paper is concerned with global estimates and regularity of solutions for the initial value problem of the retarded parabolic equation $$\frac{\patial u}{\patial t}-\Delta u=f(x,u)+g(u(x,t-r_1(t)),\cdots,u(x,t-r_m(t)))+h(x,t)$$ in a bounded domain $\Omega\subset R^n$ with fast-growing nonlinearities and a dissipative structure, which is associated ...
arxiv