INFAD, 2017 Fragility is an increase in the vulnerability to stressors of low intensity, produced by an alteration in multiple and interrelated systems, which leads to a decrease in the homeostatic reserve and the capacity of adaptation of the organism, which ...
Álvaro Da Silva González +1 more
doaj +3 more sources
Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women [PDF]
Alzheimers DementAbstract Background Both nulliparity and multiparity have been linked to an increased risk of dementia. However, evidence is inconclusive and requires further study. To further investigate the link between pregnancy history and cognition, we explored the link between age at first childbirth and cognitive change in cognitively unimpaired (CU) women and ...
Brugulat‐Serrat A +10 more
europepmc +2 more sources
Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum [PDF]
Alzheimers DementAbstract Background Altered resting‐state functional connectivity (RSFC) has been reported in early Alzheimer's disease (AD). Graph metrics derived from RSFC networks provide valuable insights into brain organization. However, their potential in characterizing early network dysfunction and their relationship with AD biomarkers and cognitive performance
Lizarraga A +14 more
europepmc +2 more sources
Microglial reactivity attenuates ptau231‐related amyloid accumulation in preclinical Alzheimer’s disease [PDF]
Alzheimers DementAbstract Background Recent studies indicate that soluble tau phosphorylated at threonine 231 (p‐tau231) rises most prominently in the earliest preclinical stages of Alzheimer's disease (AD), preceding overt amyloid‐beta (Aβ) PET positivity. Elevated p‐tau231 levels may promote emerging Aβ deposition, but the biological mechanisms linking early tau ...
Pelkmans W +9 more
europepmc +3 more sources
Predicting cognitive trajectories in asymptomatic individuals at‐risk of AD: insights from a multi‐platform plasma proteomics study [PDF]
Alzheimers DementAbstract Background Plasma biomarkers enabling early detection of Alzheimer's disease (AD) biological hallmarks are now available. Yet, predicting cognitive decline in at‐risk individuals remains challenging due to the high variability of cognitive outcomes and lack of reliable prognostic markers.
Anastasi F +10 more
europepmc +2 more sources
Synergistic Effects of Plasma p‐tau217 and GFAP on Neurodegeneration and Cognitive Decline in Cognitively Unimpaired Individuals [PDF]
Alzheimers DementAbstract Background Plasma phosphorylated tau at threonine 217 (p‐tau217) is an accurate biomarker for Alzheimer's pathology. Emerging data suggest that plasma p‐tau217, especially when combined with Glial Fibrillary Acidic Protein (GFAP), predicts cognitive decline up to a decade before clinical onset. However, no studies have quantified its impact on
Cacciaglia R +11 more
europepmc +2 more sources
Analysis of perivascular spaces highlights regional enlargement by sex, amyloid status, AD genetic predisposition and specific risk factors [PDF]
Alzheimers DementAbstract Background Perivascular spaces (PVS), fluid‐filled compartments around brain blood vessels, are markers of small vessel disease and overall brain health. Key to the glymphatic system, they aid in waste clearance and may influence neuroinflammation.
Fernández‐Bonet A +14 more
europepmc +2 more sources
Exploring the impact of childbirth on the association between white matter hyperintensity load and cognitive changes in post‐menopausal women at risk of Alzheimer's Disease [PDF]
Alzheimers DementAbstract Background Cerebrovascular diseases impact cognition in middle‐aged individuals. Hormonal changes caused by childbirth impact the cerebrovascular system, yet little is known about its influence on cognition. We examined the influence of associations between number of childbirths and white matter hyperintensities (WMH) on cognitive change, in ...
Gallay C +10 more
europepmc +2 more sources
Cerebral glucose metabolism and regional homogeneity as predictors of amyloid burden changes in preclinical AD [PDF]
Alzheimers DementAbstract Background Regional homogeneity (ReHo) is a widely used measure in resting‐state functional magnetic resonance imaging (rs‐fMRI) for assessing the coherence of blood oxygen level‐dependent (BOLD) fMRI timeseries among contiguous brain regions.
Kassinopoulos M +14 more
europepmc +2 more sources
Revue d'anthropologie des connaissances, 2023 Este artículo introductorio muestra cómo el prisma de la fragilidad permite ampliar conceptual y empíricamente los trabajos que, centrándose en la agentividad de los objetos y materiales, han hecho hincapié en la parte material de las sociedades humanas.
Denis, Jérôme, Pontille, David
openaire +6 more sources