Results 41 to 50 of about 3,471 (176)
Acta Physiologica, Volume 242, Issue 3, March 2026.ABSTRACT Aim Mitochondrial dysfunction plays a central role in multiple neurodegenerative diseases, yet the temporal sequence of cellular events underlying neurodegeneration remains poorly defined. This study aimed to characterize the progression of neurodegeneration in a mouse model of fatal mitochondrial encephalopathy and to evaluate the therapeutic
Laura Jiménez‐Sánchez +12 more
wiley +1 more source
International Journal of Developmental and Educational Psychology. Revista INFAD de psicología, 2014 Introducao: O diagnostico da fragilidade e complexo e dificil. O medico de Medicina Geral e Familiar desempenha um papel fundamental na identificacao precoce dos idosos frageis. Objetivo: Clarificar e propor a comunidade clinica em Portugal o conceito de fragilidade nos cuidados de saude primarios e continuadas para que se adapte e valide ...
Mário Joaquim do Carmo Pereira Pinto +1 more
openaire +1 more source
Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 658-668, March 2026.Clinical management of the older adult. ABSTRACT Objectives Frailty is a common condition in community‐dwelling older adults with high health and socioeconomic implications. However, primary care‐led randomized trials have been scarcely tested. Design Multicenter cluster randomized clinical trial.
Adriana Abizanda Saro +86 more
wiley +1 more source
Fragilidad en ancianos hospitalizados en un servicio de medicina interna
Revista Cubana de Medicina Militar, 2019 Introducción: El síndrome de fragilidad es consecuencia de la disminución en la resistencia y reservas fisiológicas del anciano, que lo hace vulnerable a efectos adversos para la salud.
Antonio Belaunde Clausell +2 more
doaj
Enfermería Nefrológica, 2023 Introducción: El síndrome de fragilidad en pacientes en diálisis puede deteriorar la calidad de vida relacionada con la salud. Objetivo: Analizar la asociación entre el síndrome de fragilidad y la calidad de vida relacionada con la salud en pacientes en
Melanie Christy Peralta-Flores +3 more
doaj +1 more source
Experimental Physiology, Volume 111, Issue 3, Page 1498-1512, 1 March 2026.Abstract figure T‐type VGCCs contribute to the contraction of the rabbit aorta and modulate both contraction and vasodilation in the rabbit renal artery. α1, alpha 1 adrenergic receptor; ATR, angiotensin II receptor; Ang II, angiotensin II; CaM, calmodulin; Cav3, T‐type voltage‐gated Ca2⁺ channels; cGMP, cyclic guanidine monophosphate; EC, endothelial ...
Andrea Suarez +6 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Sensitive memory paradigms may allow the detection of subtle memory changes associated with early Alzheimer's pathology in individuals without established clinical symptomatology. METHODS We explored the cross‐sectional association between performance on Tablet‐based Cognitive Assessment Tool (TabCAT) Favorites, a brief ...
Anna Brugulat‐Serrat +9 more
wiley +1 more source
Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Sleep disruption, particularly loss of slow‐wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations.
Neus Falgàs +20 more
wiley +1 more source
Tecnología y ciencias del agua, 2018 El presente artículo describe un enfoque original para determinar curvas de fragilidad de bordos perimetrales, ante la falla por erosión debida al desbordamiento basado en la simulación de variables aleatorias. El análisis de fragilidad toma en cuenta la
Guillén F. Vázquez +2 more
doaj
Aging Cell, Volume 25, Issue 2, February 2026.In frail older adults, a 6‐month lifestyle intervention slowed epigenetic aging and improved functional outcomes, suggesting lifestyle strategies may delay biological aging and disability progression. ABSTRACT Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical ...
Gloria Olaso‐Gonzalez +13 more
wiley +1 more source