Results 261 to 270 of about 8,391,091 (301)

Dismantling the Fragility Index: A demonstration of statistical reasoning

Statistics in Medicine, 2020
The Fragility Index has been introduced as a complement to the P‐value to summarize the statistical strength of evidence for a trial's result. The Fragility Index (FI) is defined in trials with two equal treatment group sizes, with a dichotomous or time ...
Gail Potter
exaly   +5 more sources

The Fragility Index in Hand Surgery Randomized Controlled Trials

Journal of Hand Surgery, 2019
PURPOSE Randomized controlled trials (RCTs) are the gold standard for comparing clinical interventions. Statistical significance as reported via a P value has been used to determine if a difference between clinical interventions exists in an RCT. However,
Joseph J Ruzbarsky, Sariah Khormaee
exaly   +2 more sources

The fragility index and reverse fragility index of FDA investigational device exemption trials in spinal fusion surgery: a systematic review

European Spine Journal
Andrew Moon, Joshua Proal
exaly   +2 more sources

A critique of the fragility index

The Lancet Oncology, 2019
In The Lancet Oncology , Joseph Del Paggio and Ian Tannock report on a retrospective analysis of the fragility indices of phase 3 trials used by the US Food and Drug Administration (FDA) to approve anticancer drugs. 1 The authors conclude that “many phase 3 randomised controlled trials supporting FDA-approved anticancer drugs have a low fragility index,
Machado, Tiago, Duarte, Gonçalo Silva, Gonçalves, Nilza C., Ferreira, Joaquim J., Costa, João   +4 more
  +8 more sources

Reverse Fragility Index Comparing Rates of Rerupture After Open Achilles Tendon Repair Versus Early Functional Rehabilitation: A Systematic Review of Randomized Controlled Trials

American Journal of Sports Medicine, 2023
Background: Despite similar published rates of rerupture among patients treated with early functional rehabilitation and open repair for acute Achilles tendon rupture, uncertainty still exists regarding the optimal treatment modality.
Jack T. Bragg, V. Ruelos, J. McIntyre, Richard N. Puzzitiello, Nicholas R. Pagani, Mariano E. Menendez, Michael A. Moverman, Matthew J. Salzler   +7 more
semanticscholar   +1 more source

The Reverse Fragility Index for Mortality Endpoints in Randomized Trials Comparing Uncemented and Cemented Hemiarthroplasty for Intracapsular Hip Fractures.

Journal of Arthroplasty, 2023
BACKGROUND Interpreting clinical relevance of randomized controlled trials (RCTs) is challenging when P-values are marginally above or below the P=0.05 threshold.
Michael Mazzucco, Amy Z. Lu, Mohit Bhandari, N. Piuzzi, K. Kunze   +4 more
semanticscholar   +1 more source

Thresholds for interpreting the fragility index derived from sample of randomised controlled trials in cardiology: a meta-epidemiologic study

BMJ evidence-based medicine, 2022
The fragility index (FI) was proposed as a simplified way to communicate robustness of statistically significant results and their susceptibility to a change of a handful number of events. While this index is intuitive, it is not anchored by a cut-off or
M. Murad, Abdalla Kara Balla, M. S. Khan, Asim Shaikh, S. Saadi, Zhen Wang   +5 more
semanticscholar   +1 more source

The Reverse Fragility Index: Interpreting the Current Literature on Long-Term Survivorship of Computer-Navigated Versus Conventional TKA

Journal of Bone and Joint Surgery. American volume, 2022
Background: Despite the most recent American Academy of Orthopaedic Surgeons clinical practice guideline making a “strong” recommendation against the use of intraoperative navigation in total knee arthroplasty (TKA), its use is increasing.
Jeffrey L. Shi, Edward S. Mojica, Michael A. Moverman, Nicholas R. Pagani, Richard N. Puzzitiello, Mariano E. Menendez, Matthew J. Salzler, M. Gordon, J. Bono   +8 more
semanticscholar   +1 more source

The Fragility Index of Total Hip Arthroplasty Randomized Control Trials: A Systematic Review

Journal of the American Academy of Orthopaedic Surgeons, 2022
Introduction: Although randomized controlled trials (RCTs) are considered the benchmark study design, a change of outcomes for a few patients can lead to a reversal of study conclusions. As such, examination of the fragility index (FI) of RCTs has become
Cammille C. Go, David R. Maldonado, Beatrice Go, Shawn Annin, Benjamin R. Saks, Andrew E. Jimenez, B. Domb   +6 more
semanticscholar   +1 more source

The Fragility Index of Statistically Significant Findings From Randomized Controlled Trials Comparing the Management Strategies of Anterior Shoulder Instability

American Journal of Sports Medicine, 2022
Background: Debate centering on the management of anterior shoulder instability (ASI) in recent years has led to many randomized controlled trials (RCTs) being published on the topic. The fragility index (FI) has subsequently emerged as a novel method of
M. Davey, E. Hurley, Tom R. Doyle, Hasan Dashti, M. Gaafar, H. Mullett   +5 more
semanticscholar   +1 more source