Results 201 to 210 of about 92,560 (238)

Tethering: Fragment-Based Drug Discovery

Annual Review of Biophysics and Biomolecular Structure, 2004
▪ Abstract  The genomics revolution has provided a deluge of new targets for drug discovery. To facilitate the drug discovery process, many researchers are turning to fragment-based approaches to find lead molecules more efficiently. One such method, Tethering 1 , allows for the identification of small-molecule fragments that bind to specific regions ...
James Wells
exaly   +3 more sources

Counting on Fragment Based Drug Design Approach for Drug Discovery

Current Topics in Medicinal Chemistry, 2019
Fragment based drug design (FBDD) is a structure guided ligand design approach used in the process of drug discovery. It involves identification of low molecular weight fragments as hits followed by determination of their binding mode using X-ray crystallography and/or NMR spectroscopy.
Om Silakari, Pankaj Kumar Singh, Aanchal Kashyap   +2 more
exaly   +3 more sources

What is the Future for Fragment-Based Drug Discovery?

Future Medicinal Chemistry, 2017
György M Keserű, Michael Hann
exaly   +3 more sources

Fragment-Based Drug Discovery

Journal of Medicinal Chemistry, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Daniel A, Erlanson, Robert S, McDowell, Tom, O'Brien   +2 more
openaire   +3 more sources

Fragonomics: fragment-based drug discovery

Current Opinion in Chemical Biology, 2005
The use of smaller molecules (fragments) in the drug discovery process has led to success in delivering novel leads for many different targets. This process is a highly integrated process, starting from library design to screening and medicinal chemistry.
Edward R, Zartler, Michael J, Shapiro
openaire   +2 more sources

Experiences in fragment-based drug discovery

Trends in Pharmacological Sciences, 2012
Fragment-based drug discovery (FBDD) has become established in both industry and academia as an alternative approach to high-throughput screening for the generation of chemical leads for drug targets. In FBDD, specialised detection methods are used to identify small chemical compounds (fragments) that bind to the drug target, and structural biology is ...
Christopher W, Murray, Marcel L, Verdonk, David C, Rees   +2 more
openaire   +2 more sources

The rise of fragment-based drug discovery

Nature Chemistry, 2009
The search for new drugs is plagued by high attrition rates at all stages in research and development. Chemists have an opportunity to tackle this problem because attrition can be traced back, in part, to the quality of the chemical leads. Fragment-based drug discovery (FBDD) is a new approach, increasingly used in the pharmaceutical industry, for ...
Christopher W, Murray, David C, Rees
openaire   +2 more sources

Recent Developments in Fragment-Based Drug Discovery

Journal of Medicinal Chemistry, 2008
The field of fragment-based drug discovery (FBDD) has developed significantly over the past 10 years and is now recognized as a tangible alternative to more traditional methods of hit identification, such as high throughput screening (HTS). The number of commercial and academic groups actively engaged in fragment-based research has increased, and as a ...
Miles, Congreve, Gianni, Chessari, Dominic, Tisi, Andrew J, Woodhead   +3 more
openaire   +2 more sources

Fragment Based Drug Discovery - A Tool for Drug Discovery

International Journal of Drug Design and Discovery
Since the early 1990s, several technological and scientific advances — such as combinatorial chemistry, high-throughput screening and the sequencing of the human genome — have been developed for discovery of new drug entity. However, the return on investment in terms of marketed products has not met expectations.
Toraskar M.P., Singasane N.S, Pichake J.B., Vilasrao Kadam   +3 more
openaire   +1 more source

Computational Techniques in Fragment Based Drug Discovery

Current Topics in Medicinal Chemistry, 2007
Fragment based drug discovery is gaining acceptance as a complement to other more established techniques to identify leads and optimize drug candidates. In this review we illustrate areas where fragment based drug discovery has had an impact and point to some examples that show how fragment based analysis is being applied to new arenas. The traditional
Hugo O, Villar, Mark R, Hansen
openaire   +2 more sources