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The cell surface protein CD83 belongs to the immunoglobulin superfamily and is highly expressed on mature dendritic cells. The soluble form of CD83, sCD83, is a potential immune suppressor.
Lin Wan, Younan Chen, Chengshi Wang
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An interesting format in the development of therapeutic monoclonal antibodies uses the crystallizable fragment of IgG1 as starting scaffold. Engineering of its structural loops allows generation of an antigen binding site.
Balder Lai +2 more
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Engineering the Fragment Crystallizable (Fc) Region of Human IgG1 Multimers and Monomers to Fine-Tune Interactions With Sialic Acid-Dependent Receptors [PDF]
Multimeric fragment crystallizable (Fc) regions and Fc-fusion proteins are actively being explored as biomimetic replacements for intravenous immunoglobulin (IVIG) therapy, which is deployed to manage many diseases and conditions but is expensive and not
Richard J. Pleass +2 more
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Computational and Structural Biotechnology Journal, 2021
Hae Gon Lee, Shinill Kang, Joon-Hyuk Lee
exaly
Hae Gon Lee, Shinill Kang, Joon-Hyuk Lee
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