Results 71 to 80 of about 8,345 (257)

Tafasitamab for the treatment of patients with diffuse large B-cell lymphoma

Human Vaccines & Immunotherapeutics
Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) require additional treatments, especially those not eligible or not responding to high dose cytotoxic chemotherapy and stem cell transplantation.
Maria Cristina Pirosa, Anastasios Stathis, Emanuele Zucca   +2 more
doaj   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus

Emerging Microbes and Infections
In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to the scarcity of targeted antiviral interventions.
Zuning Ren, Mengjun Li, Jiayin Chen, Xiaohua Gong, Shuo Song, Delin Li, Minghui Yang, Jianhai Yu, Sadia Asghar, Yanxin Cui, Shiyu Niu, Zhonghui Liao, Yushan Jiang, Jiahui Liu, Yuqing Li, Bao Zhang, Wei Zhao, Jie Peng, Yang Yang, Chenguang Shen   +19 more
doaj   +1 more source

Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis

mBio, 2018
Pediatric meningococcal sepsis often results in morbidity and/or death, especially in young children. Our understanding of the reasons why young children are more susceptible to both the meningococcal infection itself and a more fulminant course of the ...
Noortje de Haan, Navin P. Boeddha, Ebru Ekinci, Karli R. Reiding, Marieke Emonts, Jan A. Hazelzet, Manfred Wuhrer, Gertjan J. Driessen   +7 more
doaj   +1 more source

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. [PDF]

, 2018
Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1-3.
Bat-Erdene, Undramaa, Gan, Jianhua, Jacobsen, Steven E, Liu, Qikun, Nguyen, Calvin, Tang, Yi, Yan, Yan, Yuan, Shuguang, Zang, Xin, Zhou, Jiahai   +9 more
core  

Bifunctional Surfaces With Immobilized Antibodies and Bioactive Peptides Mediate Selective Capture and Proliferation of Endothelial Colony‐Forming Cells

Advanced Healthcare Materials, EarlyView.
A tunable bifunctional surface is developed by combining Fc‐binding peptides and RGD motifs to present oriented antibodies alongside integrin‐mediated signaling. The platform selectively captures endothelial colony‐forming cells while promoting their adhesion and proliferation.
Hugo A. Level, Marc‐Antoine Campeau, Mohamed A. Elkhodiry, Gaétan Laroche, Jean‐François Tanguay, Corinne A. Hoesli   +5 more
wiley   +1 more source

Astma ning selle ravi omalizumabiga: toime, ohutus ja kasutamine lastel [PDF]

, 2017
Bronhiaalastma on maailmas üks levinumaid haigusi, millele endiselt otsitakse tõhusamaid ravimeid. Kliinilises praktikas üle kümne aasta kasutatud immunoglobuliin E vastase monokloonse antikeha omalizumabi toime põhimõte on teada, kuid vaja on täpsustada,
Lääts, Liis
core   +2 more sources

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Immunoglobulin-Related Fibroinflammatory Diseases of Uncertain Etiology—Polarized Isotype Switching Connects an Ancient with a Contemporary Disease

Lymphatics
IgG4 is an unusual immunoglobulin (Ig) and is the least component of IgG in humans. It is often asymmetrical and heterobivalent with weak Fc (fragment crystallizable region)-dependent effector function and ineffective complement activation, thus playing ...
Chi Sing Ng
doaj   +1 more source

Ask a pathologist [PDF]

, 2017
Question and answer regarding a patient who became acutely thrombocytopenic.Includes bibliographical ...
Coberly, Emily, Scheitler, Kristen
core