Results 71 to 80 of about 4,409,486 (250)

Immunoglobulin-Related Fibroinflammatory Diseases of Uncertain Etiology—Polarized Isotype Switching Connects an Ancient with a Contemporary Disease

Lymphatics
IgG4 is an unusual immunoglobulin (Ig) and is the least component of IgG in humans. It is often asymmetrical and heterobivalent with weak Fc (fragment crystallizable region)-dependent effector function and ineffective complement activation, thus playing ...
Chi Sing Ng
doaj   +1 more source

Fragment-to-Lead Medicinal Chemistry Publications in 2020

, 2021
Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies that were published in 2020. Having systematically analyzed annual scientific outputs since 2015,
Wolfgang Jahnke (1570930), Daniel A. Erlanson (2516749), Louise Walsh, Christopher N. Johnson, Wolfgang Jahnke, Daniel A. Erlanson, Iwan J. P. de Esch (7900115), Louise Walsh (1786558), Iwan J. P. de Esch, Christopher N. Johnson (157130)   +9 more
core   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Table_1_Immunoglobulin G Fragment Crystallizable Glycosylation After Hematopoietic Stem Cell Transplantation Is Dissimilar to Donor Profiles.XLSX

, 2018
Immunoglobulin G (IgG) fragment crystallizable (Fc) N-glycosylation has a large influence on the affinity of the antibody for binding to Fcγ-receptors (FcγRs) and C1q protein, thereby influencing immune effector functions.
Gertjan J. Driessen (3366869), Manfred Wuhrer (200842), Noortje de Haan (1548634), Maarten J. D. van Tol (5333453), Arjan C. Lankester (624831)   +4 more
core   +1 more source

Pulsed Laser‐Assisted Phase Engineering of Multimetallic Colloidal Nanocrystals With Complex Compositions

Advanced Materials, EarlyView.
The engineering of colloidal nanocrystals with complex compositions has emerged as a highly active area of research within nanomaterials science. This review covers key aspects of colloidal solid‐solution nanocrystal formation using pulsed laser irradiation.
Marina T. Candela, Sergio Triviño‐Sánchez, Andrés Guerrero‐Martínez, Luis M. Liz‐Marzán, Guillermo González‐Rubio   +4 more
wiley   +1 more source

LOW-TEMPERATURE, LOW-DIELECTRIC, CRYSTALLIZABLE GLASS COMPOSITE

, 2011
[[abstract]]A low k crystallizable glass composite containing borosilicate glass and cordierite glass has been developed. Crystallization and densification of cordierite glass is enhanced with borosilicate glass present.
JEAN JH;LIN SC;CHANG CR
core   +1 more source

Metabolic reprogramming of monocytes promotes pro-inflammatory properties, MDSC crosstalk, and S. aureus biofilm clearance.

, 2020
Nanoparticles containing the ATP synthase inhibitor oligomycin are targeted to Fc-receptor positive monocytes with tuftsin. Upon internalization, oligomycin inhibits ATP synthase of the mitochondrial electron transport chain and induces metabolic ...
Kelsey J. Yamada (6175994), Cortney E. Heim (8393421), Kuldeep S. Attri (8544639), Tammy Kielian (116814), Dezhen Wang (3992372), Wenting Zhang (342162), Pankaj K. Singh (179340), Tatiana K. Bronich (1902829), Xinyuan Xi (6648590)   +8 more
core   +1 more source

Phase Engineering of Nanomaterials (PEN): Evolution, Current Challenges, and Future Opportunities

Advanced Materials, EarlyView.
This review summarizes the synthesis, phase transition, advanced characterization spanning ex situ to in situ and operando techniques, and diverse applications of phase engineering of nanomaterials (PEN). It further outlines key challenges and future opportunities, such as phase stability, architecture control, and artificial intelligence (AI)‐driven ...
Ye Chen, Zhanxi Fan, Jingjie Ge, Qiyuan He, Zhuangchai Lai, Jiawei Liu, Chaoliang Tan, Hua Zhang   +7 more
wiley   +1 more source

Generation and preclinical assessment of depemokimab, an enhanced IL-5 antagonist monoclonal antibody

Heliyon
This study describes the affinity maturation, molecular engineering, and preclinical assessment of depemokimab, an enhanced anti-interleukin-5 antagonist antibody.
Martin Orecchia, Katherine Welbeck, Jason Dexter, Laura Hook, Chika Akinseye, Marcin Kot, Alan Lewis, Don Somers, Tejinder Bhinder, Paul Hamblin, Sarah Elsey, David Willé, Steven Grant   +12 more
doaj   +1 more source