Results 101 to 110 of about 711,917 (340)

Projecting Urbanization and Landscape Change at Large Scale Using the FUTURES Model

Land, 2019
Increasing population and rural to urban migration are accelerating urbanization globally, permanently transforming natural systems over large extents.
Derek Van Berkel, Ashwin Shashidharan, Rua S. Mordecai, Raju Vatsavai, Anna Petrasova, Vaclav Petras, Helena Mitasova, John B. Vogler, Ross K. Meentemeyer   +8 more
doaj   +1 more source

Fragmentation at height associated to Lévy processes [PDF]

Stochastic processes and their applications 117 (2007) 297-311, 2006
We consider the height process of a L\'{e}vy process with no negative jumps, and its associated continuous tree representation. Using tools developed by Duquesne and Le Gall, we construct a fragmentation process at height, which generalizes the fragmentation at height of stable trees given by Miermont.
arxiv  

Observing the fragmentation of two expanding bullet types and a full metal-jacketed bullet with computed tomography—a forensic ballistics case study [PDF]

, 2023
Petteri Oura, Jaakko Niinimäki, Mikael Brix, Eveliina Lammentausta, Timo Liimatainen, Alina Junno, Juho‐Antti Junno   +6 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Exploration of Sleep as a Specific Risk Factor for Poor Metabolic and Mental Health: A UK Biobank Study of 84,404 Participants

Nature and Science of Sleep, 2021
Gewei Zhu,1 Sophie Cassidy,2 Hugo Hiden,3 Simon Woodman,3 Michael Trenell,4 David A Gunn,5 Michael Catt,6 Mark Birch-Machin,1,6 Kirstie N Anderson7 1Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University ...
Zhu G, Cassidy S, Hiden H, Woodman S, Trenell M, Gunn DA, Catt M, Birch-Machin M, Anderson KN   +8 more
doaj  

Evaluation of computed tomography obstruction index in guiding therapeutic decisions and monitoring percutanous catheter fragmentation in massive pulmonary embolism [PDF]

, 2011
Tongfu Yu, Mei Yuan, Qingbo Zhang, Haibing Shi, Wang De-hang   +4 more
openalex   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Daughter Fragmentation is Unlikely To Occur in Self-Gravitating Circumstellar Discs [PDF]

arXiv, 2016
Circumstellar discs are thought to be self-gravitating at very early times. If the disc is relatively cool, extended and accreting sufficiently rapidly, it can fragment into bound objects of order a few Jupiter masses and upwards. Given that the fragment's initial angular momentum is non-zero, and it will continue to accrete angular momentum from the ...
arxiv