Results 111 to 120 of about 711,917 (340)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

A numerical framework for computing steady states of structured population models and their stability

Mathematical Biosciences and Engineering, 2017
Structured population models are a class of general evolution equations which are widely used in the study of biological systems. Many theoretical methods are available for establishing existence and stability of steady states of general evolution ...
Inom Mirzaev, David M. Bortz
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Modeling warm dense matter experiments using the 3D ALE-AMR code and the move toward exascale computing

EPJ Web of Conferences, 2013
The Neutralized Drift Compression Experiment II (NDCX II) is an induction accelerator planned for initial commissioning in 2012. The final design calls for a 3 MeV, Li+ ion beam, delivered in a bunch with characteristic pulse duration of 1 ns, and ...
Koniges Alice, Liu Wangyi, Barnard John, Friedman Alex, Logan Grant, Eder David, Fisher Aaron, Masters Nathan, Bertozzi Andrea   +8 more
doaj   +1 more source

The Adjacent Fragment and Quine's Limits of Decision [PDF]

arXiv
We introduce the adjacent fragment AF of first-order logic, obtained by restricting the sequences of variables occurring as arguments in atomic formulas. The adjacent fragment generalizes (after a routine renaming) the two-variable fragment of first-order logic as well as the so-called fluted fragment.
arxiv  

Correction to Computing Fragmentation Trees from Tandem Mass Spectrometry Data [PDF]

, 2011
Florian Rasche, Aleš Svatoš, Ravi Kumar Maddula, Christoph Böttcher, Sebastian Böcker   +4 more
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

One-dimensional fragment of first-order logic [PDF]

arXiv, 2014
We introduce a novel decidable fragment of first-order logic. The fragment is one-dimensional in the sense that quantification is limited to applications of blocks of existential (universal) quantifiers such that at most one variable remains free in the quantified formula.
arxiv  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Ultra-Efficient Kidney Stone Fragment Removal via Spinner-Induced Synergistic Circulation and Spiral Flow [PDF]

arXiv
Kidney stones can cause severe pain and complications such as chronic kidney disease or kidney failure. Retrograde intrarenal surgery (RIRS), which uses laser lithotripsy to fragment stones for removal via a ureteroscope, is widely adopted due to its safety and effectiveness.
arxiv