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Data confidentiality using fragmentation in cloud computing
International Journal of Pervasive Computing and Communications, 2013 PurposeThe aim of this research is to secure the sensitive outsourced data with minimum encryption within the cloud provider. Unfaithful solutions for providing privacy and security along with performance issues by encryption usage of outsourced data are the main motivation points of this research.Design/methodology/approachThis paper presents a method
Aleksandar Hudic +4 more
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Computational studies on fragmentation of brittle materials [PDF]
Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 2012 We study dynamic fragmentation of metallic structures using the cracking particles method with obscuration zone. The cracking particles method is an efficient meshfree method for modeling dynamic fracture. Fracture is modeled by a set of crack segments. The cracking particles method does not require the representation of the crack topology.
Ghosh, Arindam, Kumar, V.
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Computational Approaches for Fragment Optimization
Current Computer Aided-Drug Design, 2007Fragment based screening has become a valuable tool to complement traditional lead finding methods like high throughput screening in drug discovery. Fragments are low molecular mass compounds and are usually screened using high sensitivity biophysical methods which are suitable for the detection of weakly binding ligands.
Simon Rüdisser, Eric Vangrevelinghe
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The role of fragment-based and computational methods in polypharmacology
Drug Discovery Today, 2012Polypharmacology-based strategies are gaining increased attention as a novel approach to obtaining potentially innovative medicines for multifactorial diseases. However, some within the pharmaceutical community have resisted these strategies because they can be resource-hungry in the early stages of the drug discovery process.
Maurizio Recanatini +4 more
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Fragment Informatics and Computational Fragment‐Based Drug Design: An Overview and Update
Medicinal Research Reviews, 2012AbstractFragment‐based drug design (FBDD) is a promising approach for the discovery and optimization of lead compounds. Despite its successes, FBDD also faces some internal limitations and challenges. FBDD requires a high quality of target protein and good solubility of fragments.
Chunquan Sheng, Wannian Zhang
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Virtual Fragment Preparation for Computational Fragment-Based Drug Design [PDF]
, 2015 Fragment-based drug design (FBDD) has become an important component of the drug discovery process. The use of fragments can accelerate both the search for a hit molecule and the development of that hit into a lead molecule for clinical testing.
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Computational Techniques in Fragment Based Drug Discovery
Current Topics in Medicinal Chemistry, 2007Fragment based drug discovery is gaining acceptance as a complement to other more established techniques to identify leads and optimize drug candidates. In this review we illustrate areas where fragment based drug discovery has had an impact and point to some examples that show how fragment based analysis is being applied to new arenas. The traditional
Mark R. Hansen, Hugo O. Villar
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Computational Models for Fragmentation Tests
1993The transfer of stress between an embedded fibre and a surrounding matrix, and vice versa, is achieved either by means of a bonding mechanism which can include combinations of chemical bonding, mechanical interlock and slip mechanisms which can include friction between the matrix and the fibre.
A. P. S. Selvadurai +2 more
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Computational Tools for In Silico Fragment-Based Drug Design
Current Topics in Medicinal Chemistry, 2012Fragment-based strategy in drug design involves the initial discovery of low-molecular mass molecules. Owing to their small-size, fragments are molecular tools to probe specific sub-pockets within a protein active site. Once their interaction within the enzyme cavity is clearly understood and experimentally validated, they represent a unique ...
Jérémie Mortier +3 more
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Blood Coagulation & Fibrinolysis, 1991
We describe a program GENESRCH which has been written to enable the design of efficient restriction fragment analysis of DNA from patients with hereditary disorders. The program identifies homology of DNA sequences up to 20 base pairs in length, calculates the fragment sizes and indicates the position of enzyme restriction sites within the gene of ...
Warnock Lj, Preston Fe, Brown P
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We describe a program GENESRCH which has been written to enable the design of efficient restriction fragment analysis of DNA from patients with hereditary disorders. The program identifies homology of DNA sequences up to 20 base pairs in length, calculates the fragment sizes and indicates the position of enzyme restriction sites within the gene of ...
Warnock Lj, Preston Fe, Brown P
openaire +3 more sources