Results 41 to 50 of about 711,917 (340)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Antenna subtraction for processes with identified particles at hadron colliders

Journal of High Energy Physics
Collider processes with identified hadrons in the final state are widely studied in view of determining details of the proton structure and of understanding hadronization.
Leonardo Bonino, Thomas Gehrmann, Matteo Marcoli, Robin Schürmann, Giovanni Stagnitto   +4 more
doaj   +1 more source

Computer‐based engineering of thermostabilized antibody fragments

AIChE Journal, 2019
AbstractWe used the molecular modeling program Rosetta to identify clusters of amino acid substitutions in antibody fragments (scFvs and scAbs) that improve global protein stability and resistance to thermal deactivation. Using this methodology, we increased the melting temperature (Tm) and resistance to heat treatment of an antibody fragment that ...
Wenzong Li, Oana I. Lungu, Gregory C. Ippolito, Chang-Han Lee, Jeffrey J. Gray, George Georgiou, Bryan S. Der, Bing Tan, Brian Kuhlman, R. E. Hughes, R. E. Hughes, Nicholas M. Marshall, Andrew D. Ellington, Sang Taek Jung, Yan Zhang, Aleksandr E. Miklos, Jiwon Lee, Jianqing Xu, Christos S. Karamitros, Tae Hyun Kang   +19 more
openaire   +4 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Ab initio quantum simulation of strongly correlated materials with quantum embedding

npj Computational Materials, 2023
Quantum computing has shown great potential in various quantum chemical applications such as drug discovery, material design, and catalyst optimization. Although significant progress has been made in the quantum simulation of simple molecules, ab initio ...
Changsu Cao, Jinzhao Sun, Xiao Yuan, Han-Shi Hu, Hung Q. Pham, Dingshun Lv   +5 more
doaj   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Industry 4.0 and healthcare: Context, applications, benefits and challenges

IET Software, 2023
Industry 4.0 refers to the digital transformation in the manufacturing domain through new technology. Currently, it expands well beyond manufacturing, affecting many areas of life and posing implications for all types of business.
Konstantinos Kotzias, Faiza A. Bukhsh, Jeewanie Jayasinghe Arachchige, Maya Daneva, Abhishta Abhishta   +4 more
doaj   +1 more source

Deciding the Loosely Guarded Fragment and Querying Its Horn Fragment Using Resolution [PDF]

arXiv, 2020
We consider the following query answering problem: Given a Boolean conjunctive query and a theory in the Horn loosely guarded fragment, the aim is to determine whether the query is entailed by the theory. In this paper, we present a resolution decision procedure for the loosely guarded fragment, and use such a procedure to answer Boolean conjunctive ...
arxiv  

The intuitionistic fragment of computability logic at the propositional level

Annals of Pure and Applied Logic, 2007
This paper presents a soundness and completeness proof for propositional intuitionistic calculus with respect to the semantics of computability logic. The latter interprets formulas as interactive computational problems, formalized as games between a machine and its environment.
openaire   +3 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source