Results 71 to 80 of about 711,917 (340)

The Mass Accretion Rate and Stellar Properties in Class I Protostars

open access: yesThe Astrophysical Journal, 2023
Stars collect most of their mass during the protostellar stage, yet the accretion luminosity and stellar parameters, which are needed to compute the mass accretion rate, are poorly constrained for the youngest sources.
Eleonora Fiorellino   +7 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Mapping Natural Forest Remnants with Multi-Source and Multi-Temporal Remote Sensing Data for More Informed Management of Global Biodiversity Hotspots

open access: yesRemote Sensing, 2020
Global terrestrial biodiversity hotspots (GBH) represent areas featuring exceptional concentrations of endemism and habitat loss in the world. Unfortunately, geospatial data of natural habitats of the GBHs are often outdated, imprecise, and coarse, and ...
Joni Koskikala   +2 more
doaj   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Fragmentation processes in impact of spheres [PDF]

open access: yes, 2007
We study the brittle fragmentation of spheres by using a three-dimensional Discrete Element Model. Large scale computer simulations are performed with a model that consists of agglomerates of many particles, interconnected by beam-truss elements.
arxiv   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Half-Baked Logo Microworlds as Boundary Objects in Integrated Design

open access: yesInformatics in Education, 2007
The paper addresses the problem of fragmentation of the communities involved in the design of digital media for education. It draws on the experience gained at the Educational Technology Lab in the design of Logo-based microworlds with three different ...
Chronis KYNIGOS
doaj   +1 more source

Exploring the efficacy of molecular fragments of different complexity in computational SAR modeling [PDF]

open access: yesarXiv, 2015
An important first step in computational SAR modeling is to transform the compounds into a representation that can be processed by predictive modeling techniques. This is typically a feature vector where each feature indicates the presence or absence of a molecular fragment.
arxiv  

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