Results 101 to 110 of about 3,071,234 (393)

Thermal radiation and fragmentation pathways of photo-excited silicon clusters [PDF]

The Journal of Chemical Physics, 2015
The fragmentation of laser heated silicon clusters was studied by time-of-flight mass spectrometry. For Sin+ (n = 5–19, 21), the lowest energy fragmentation pathways were identified as the metastable decay channel occurring after the primary acceleration of the ions.
Ferrari Ramirez, Piero Antonio, Janssens, Ewald, Lievens, Peter, Hansen, Klavs   +3 more
openaire   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

LC, MSn and LC–MS/MS studies for the characterization of degradation products of amlodipine

Journal of Pharmaceutical Analysis, 2015
In the present study, comprehensive stress testing of amlodipine (AM) was carried out according to International Conference on Harmonization (ICH) Q1A(R2) guideline.
Ravi N. Tiwari, Nishit Shah, Vikas Bhalani, Anand Mahajan   +3 more
doaj   +1 more source

Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells

Biotechnology Reports, 2020
Constitutive activation of NF-κB is associated with proinflammatory diseases and suppression of the NF-κB signaling pathway has been considered as an effective therapeutic strategy in the treatment of various cancers including hepatocellular carcinoma ...
Chaithanya Somu, Chakrabhavi Dhananjaya Mohan, Sachin Ambekar, Dukanya, Shobith Rangappa, CP Baburajeev, Alexey Sukhorukov, Srishti Mishra, Muthu K Shanmugam, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Basappa, Kanchugarakoppal S. Rangappa   +13 more
doaj   +1 more source

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]

, 2017
Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto, Benvenuto, Monica, Bergante, Sonia, Giganti, Maria Gabriella, Manzari, Vittorio, Masuelli, Laura, Mattera, Rosanna, Modesti, Andrea, Pluchinotta, Francesca Romana, Tettamanti, Guido, Tresoldi, Ilaria   +10 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Modulation of apoptosis by V protein mumps virus

Virology Journal, 2011
Background The Urabe AM9 vaccine strain of mumps virus contains two variants of V protein: VWT (of HN-A1081 viral population) and VGly (of HN-G1081). The V protein is a promoting factor of viral replication by blocking the IFN antiviral pathway. Findings
Herrera-Camacho Irma, Jurado Francisca, Reyes-Leyva Julio, Santos-López Gerardo, Rosas-Murrieta Nora H   +4 more
doaj   +1 more source

Strong light fields coax intramolecular reactions on femtosecond time scales

, 2004
Energetic H$_2^+$ ions are formed as a result of intra-molecular rearrangement during fragmentation of linear alcohols (methanol, ethanol, propanol, hexanol, and dodecanol) induced by intense optical fields produced by 100 fs long, infrared, laser pulses
Krishnamurthy, M., Mathur, D., Rajgara, F. A.   +2 more
core   +1 more source

Photophysics of indole upon x-ray absorption [PDF]

, 2018
A photofragmentation study of gas-phase indole (C$_8$H$_7$N) upon single-photon ionization at a photon energy of 420 eV is presented. Indole was primarily inner-shell ionized at its nitrogen and carbon $1s$ orbitals.
Anielski, Denis, Bari, Sadia, Boll, Rebecca, Bomme, Cédric, Di Fraia, Michele, Erk, Benjamin, Kienitz, Jens S., Kierspel, Thomas, Küpper, Jochen, Müller, Nele L. M., Rolles, Daniel, Trippel, Sebastian, Viefhaus, Jens, Wiese, Joss   +13 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source