Results 151 to 160 of about 3,071,234 (393)

Review for "Investigating the fragmentation pathways of β-naphthol pigments by Liquid Chromatography - Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry" [PDF]

, 2020
Kermit K. Murray, Robert K. Boyd, Marcos N. Eberlin, G. John Langley, Liang Li, Yasuhide Naito, J Todd, J Todd, K Biemann, Y.-F Liu, Z.-Y Guo, X.-Q Liu, T Qu, J.-L Xie, P Price, K Murray, R Cooks, A Rockwood, J Beynon, A Marshall, C Hendrickson, G Jackson, M Bursey, J Adams, J Lederberg, M Wightman, F Karasek, R Smythe, T Hirschfeld, S Gerber, J Rush, O Stemman, M Kirschner, S Gygi, F White, T Collins, A Bristow, K Webb, R Smith, J Loo, C Edmonds, C Barinaga, H Udseth, T Conrads, G Anderson, T Veenstra, L Paa-Toli, R Smith, P Roepstorff, J Fohlman, R Houriet, T Gumann, E Kluft, N Nibbering, H Lumpkin, G Taylor, R Houriet, T Elwood, J Futrell, N Shuman, W Stevens, K Lower, T Baer, R Cooks, Z Ouyang, Z Takats, J Wiseman, T Annesley, B Gulbakan, E Yasun, M Shukoor, Z Zhu, M You, X Tan, H Sanchez, D Powell, H Dai, W Tan, P Hemberger, J Larame, A Hubik, R Cooks, L Van Vaeck, H Struyf, W Roy, F Adams, J Hill, S Martin, J Biller, K Biemann, L Taylor, D Brent, J Cottrell, D Bohme, D Dunkin, F Fehsenfeld, E Ferguson, D Carroll, I Dzidic, R Stillwell   +99 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]

, 2020
Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Meng, Xiao-Wen, Peng, Ke, Xia, Fan, Xia, Zheng-Yuan, Zhang, Juan   +8 more
core  

dGPredictor: Automated fragmentation method for metabolic reaction free energy prediction and de novo pathway design

, 2021
Lin Wang, Vikas Upadhyay, Costas D. Maranas   +2 more
openalex   +1 more source

Comparing Fragmentation Trees from Electron Impact Mass Spectra with Annotated Fragmentation Pathways

, 2012
Electron impact ionization (EI) is the most common form of ionization for GC-MS analysis of small molecules. This ionization method results in a mass spectrum not necessarily containing the molecular ion peak. The fragmentation of small compounds during EI is well understood, but manual interpretation of mass spectra is tedious and time-consuming ...
Hufsky, Franziska, Böcker, Sebastian
openaire   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Development of Sequence‐Controlled, Degradable, and Cytocompatible Oligomers with Explicit Fragmentation Pathways [PDF]

, 2023
Yili Yang, Keman Yu, Feiyue Xing, Yingshan Zhou, Pu Xiao   +4 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Tipping the balance: theoretical interrogation of divergent extended heterolytic fragmentations. [PDF]

, 2020
Herein we interrogate a type of heterolytic fragmentation reaction called a 'divergent fragmentation' using density functional theory (DFT), natural bond orbital (NBO) analysis, ab initio molecular dynamics (AIMD), and external electric field (EEF ...
Laconsay, Croix J, Tantillo, Dean J, Tsui, Ka Yi   +2 more
core  

Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner [PDF]

, 2016
Yanfang Rui, James Q. Zheng
openalex   +1 more source