Results 11 to 20 of about 3,071,234 (393)

Mass Fragmentation Characteristics of 4 Synthetic Cathinone Isomers [PDF]

open access: yesZhipu Xuebao, 2023
Synthetic cathinones, the designer analogs of the naturally occurring cathinone found in Khat, largely entered the recreational drug market at the end of the 2000s. They are a large class of new psychoactive substances (NPS) often used as substitutes for
JIA Wei;HU Shuang;LI Tao;LIU Cui-mei;WANG You-mei;HUA Zhen-dong
doaj   +1 more source

online quantitative analysis, online process mass spectrometer, quadrupole mass spectrometer [PDF]

open access: yesZhipu Xuebao, 2023
As of October 2022, the United Nations Office on Drugs and Crime (UNODC) Early Warning Advisory (EWA) has monitored over 1 150 new psychoactive substances (NPS) that had appeared in 137 countries and territories, including 76 substances that were ...
LIU Cui-mei1   +5 more
doaj   +1 more source

Chemical Constituent Analysis of Ranunculus sceleratus L. Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole-Orbitrap High-Resolution Mass Spectrometry

open access: yesMolecules, 2022
Ranunculus sceleratus L.(RS) has shown various pharmacological effects in traditional Chinese medicine. In our previous study, the positive therapeutic effect on α-naphthylisothiocyanate induced intrahepatic cholestasis in rats was obtained using TianJiu
Shanshan Cao   +9 more
doaj   +1 more source

Alpha-synuclein fragments trigger distinct aggregation pathways [PDF]

open access: yesCell Death & Disease, 2020
AbstractAggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate therapeutic target.
Tasnim Chakroun   +9 more
openaire   +5 more sources

Unusual Fragmentation Pathways in Collagen Glycopeptides [PDF]

open access: yesJournal of the American Society for Mass Spectrometry, 2013
Collagens are the most abundant glycoproteins in the body. One characteristic of this protein family is that the amino acid sequence consists of repeats of three amino acids –(X—Y—Gly)n. Within this motif, the Y residue is often 4-hydroxyproline (HyP) or 5-hydroxylysine (HyK). Glycosylation in collagen occurs at the 5-OH group in HyK in the form of two
Irina, Perdivara   +6 more
openaire   +2 more sources

Advanced Analytical Approaches for the Analysis of Polyphenols in Plants Matrices—A Review

open access: yesSeparations, 2021
Phenolic compounds are plants’ bioactive metabolites that have been studied for their ability to confer extensive benefits to human health. As currently there is an increased interest in natural compounds identification and characterization, new ...
Elena Roxana Chiriac   +5 more
doaj   +1 more source

Comment on Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an Achillea millefolium L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against Helicobacter pylori. Antioxidants 2022, 11, 1849

open access: yesAntioxidants, 2023
Villalva et al. evaluated the potential utility of an Achillea millefolium (yarrow) extract in the control of H. pylori infection. The agar-well diffusions bioassay was applied to determine the antimicrobial activity of yarrow extracts. The supercritical
Rafał Frański   +1 more
doaj   +1 more source

In-vitro fragmentation of ovarian tissue activates primordial follicles through the Hippo pathway

open access: yesHuman Reproduction Open, 2020
STUDY QUESTION What is the role of the Hippo and PI3K/Akt pathway in follicles during ovarian tissue culture in tissue derived from oncological patients and transgender men?
C. De Roo   +3 more
semanticscholar   +1 more source

A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

open access: yesFrontiers in Cellular Neuroscience, 2022
Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease (PD), the leading causes of dementia. These neurological disorders are characterized by the accumulation of misfolded proteins such as amyloid-ß (Aß), tau protein ...
S. Saha   +4 more
semanticscholar   +1 more source

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