Results 61 to 70 of about 3,071,234 (393)

LC-MS/MS BASED DEREPLICATION OF ISOQUINOLINE-DERIVED ALKALOIDS FROM THE TRUNK BARK OF Unonopsis rufescens (Baill.) R.E.Fr. (Annonaceae) [PDF]

Química Nova
Mass spectrometry-based approaches constitute the primary strategy for the dereplication of isoquinoline-derived alkaloids, which are widely distributed in various genera of the Annonaceae family.
Lucas Antônio F. de Almeida, Felipe Moura A. da Silva, Bruna Ribeiro de Lima, Aline Bastos B. de Sousa, Francinaldo A. da Silva Filho, Brenda R. C. Leocadio, Ana Paula A. Castro, Rebeca dos S. França, Hector H. F. Koolen, Afonso D. L. de Souza, Maria Lúcia B. Pinheiro   +10 more
doaj   +1 more source

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Nucleic Acids Research, 2018
Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-transcriptionally they are heavily modified to improve their function, folding and stability.
C. Cosentino, Sanna Toivonen, Esteban Diaz Villamil, M. Atta, J. Ravanat, Stéphane Demine, A. Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, J. Jonas, Diego Balboa, T. Otonkoski, E. Pearson, P. Marchetti, D. Eizirik, M. Cnop, M. Igoillo-Esteve   +16 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes.

PLoS ONE, 2011
Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic pathway and their death during ...
Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A Cook, Joan X Comella, Daniel Sanchis   +9 more
doaj   +1 more source

From planes to bowls: photodissociation of the bisanthenequinone cation

, 2018
We present a combined experimental and theoretical study of the photodissociation of the bisanthenequinone (C28H12O2) cation, Bq+. The experiments show that, upon photolysis, the Bq+ cation does not dehydrogenate, but instead fragments through the ...
Chen, Tao, Linnartz, Harold, Tielens, Alexander G. G. M., Wang, Ying, Zhen, Junfeng   +4 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition [PDF]

, 2014
Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum.
Budrikis, Z., Costantini, G., La Porta, C. A., Zapperi, S.   +3 more
core   +3 more sources

Carbon-sulfur bond strength in methanesulfinate and benzenesulfinate ligands directs decomposition of Np(v) and Pu(v) coordination complexes. [PDF]

, 2020
Gas-phase coordination complexes of actinyl(v) cations, AnO2+, provide a basis to assess fundamental aspects of actinide chemistry. Electrospray ionization of solutions containing an actinyl cation and sulfonate anion CH3SO2- or C6H5SO2- generated ...
Gibson, John K, Gong, Yu, Réal, Florent, Saab, Mohamad, Vallet, Valérie   +4 more
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Long-time asymptotics for polymerization models [PDF]

, 2018
This study is devoted to the long-term behavior of nucleation, growth and fragmentation equations, modeling the spontaneous formation and kinetics of large polymers in a spatially homogeneous and closed environment.
Calvo, Juan, Doumic, Marie, Perthame, Benoît   +2 more
core   +4 more sources