Results 81 to 90 of about 3,071,234 (393)

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Comprehensive comparison of in silico MS/MS fragmentation tools of the CASMI contest: database boosting is needed to achieve 93% accuracy

Journal of Cheminformatics, 2017
In mass spectrometry-based untargeted metabolomics, rarely more than 30% of the compounds are identified. Without the true identity of these molecules it is impossible to draw conclusions about the biological mechanisms, pathway relationships and ...
I. Blaženović, T. Kind, Hrvoje Torbašinović, Slobodan Obrenović, S. Mehta, H. Tsugawa, Tobias Wermuth, N. Schauer, M. Jahn, R. Biedendieck, D. Jahn, O. Fiehn   +11 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mass Fragmentation Characteristics of New Psychoactive Substances of Nitazenes

Zhipu Xuebao
2-Benzylbenzimidazole opioids, also referred to “nitazenes”, has been noted with increasing frequency in the recreational drug market. These compounds were first synthesized in the 1950s, marking the pharmaceutical industry’s initial achievement of high ...
Qian-ya DENG, Jin-lun XU, Chun-fang NI, Fang-qi CAO, Yang SI, Si-yang HE, Shui-qing ZHENG, Chen LIANG   +7 more
doaj   +1 more source

Investigation of the apoptotic way induced by digallic acid in human lymphoblastoid TK6 cells

Cancer Cell International, 2012
Background The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. Methods We attempt to characterize the apoptotic pathway activated by DGA.
Bhouri Wissem, Boubaker Jihed, Skandrani Ines, Ghedira Kamel, Chekir Ghedira Leila   +4 more
doaj   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E., Estes, M. K., Guix Arnau, Susana, Katayama, K., Sharp, T. M.   +4 more
core   +2 more sources

Components of the Secondary Pathway Stimulate the Primary Pathway of Eukaryotic Okazaki Fragment Processing [PDF]

Journal of Biological Chemistry, 2010
Reconstitution of eukaryotic Okazaki fragment processing implicates both one- and two-nuclease pathways for processing flap intermediates. In most cases, FEN1 (flap endonuclease 1) is able to efficiently cleave short flaps as they form. However, flaps escaping cleavage bind replication protein A (RPA) inhibiting FEN1.
Henry, Ryan A., Balakrishnan, Lata, Ying-Lin, Stefanie Tan, Campbell, Judith L., Bambara, Robert A.   +4 more
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Research of Dehydroaromatization Reactions in the Mass Spectrometric Fragmentation of Dipine Drugs

Zhipu Xuebao
Dipine drugs, classified as dihydropyridine calcium channel antagonists, are widely utilized in clinical settings as antihypertensive vasodilator calcium antagonist to treat angina pectoris, hypertension, and coronary artery diseases.
Xiao-yun WANG, Yan-chun YUAN, Min-min DUAN, Jian-hua DING, Xiao-ping ZHANG   +4 more
doaj   +1 more source

Mass spectrometry-directed synthesis of early–late sulfide-bridged heterobimetallic complexes from the metalloligand [Pt₂(PPh₃)₄(μ-S)₂] and oxo compounds of vanadium(V), molybdenum(VI) and uranium(VI) [PDF]

, 2002
The metalloligand [Pt₂(PPh₃)₄(μ-S)₂] has been found to react with the transition metal oxo compounds, ammonium metavanadate, sodium molybdate, and the actinide complex uranyl nitrate to give sulfide-bridged heterobimetallic complexes [Pt₂(PPh₃)₄(μ₃-S)₂VO(
Fong, S.W. Audi, Henderson, William, Hor, T.S. Andy, Vittal, Jagadese J., Yap, Woon Teck   +4 more
core   +2 more sources