Results 191 to 200 of about 16,669 (298)

Natural Variation in ZmASB1 Links Tryptophan Metabolism to Root Growth and Drought Tolerance in Maize

open access: yesAdvanced Science, EarlyView.
Natural variation in the maize ZmASB1 promoter regulates tryptophan accumulation, root development, and drought tolerance through a tryptophan–auxin pathway. A 5‐bp InDel alters ZmDOF17 binding and promoter activity, and the favorable allele is enriched during breeding. These findings reveal a cis‐regulatory mechanism linking amino acid metabolism with
Xiaoyi Yang   +17 more
wiley   +1 more source

Integrating Machine Learning With Constant‐Potential Simulation to Unravel Charge‐Transfer Mechanisms in Electrochemical Nitrogen Fixation

open access: yesAdvanced Science, EarlyView.
Integrating interpretable machine learning with the fixed‐potential method reveals a novel mechanism: the catalytic activity of the electrochemical nitrogen reduction reaction is governed by partial charge transfer, induced by variations in the intermediate potential of zero charge under constant potential.
Yufei Xue   +6 more
wiley   +1 more source

Increased risk of periodontal disease and poor oral-related quality of life in fibromyalgia. [PDF]

open access: yesActa Odontol Scand
Hopkins K   +5 more
europepmc   +1 more source

Efficient Screening of Organic Singlet Fission Molecules Using Graph Neural Networks

open access: yesAdvanced Science, EarlyView.
A high‐throughput screening framework based on graph neural networks (GNNs) and multi‐level validation facilitates the identification of singlet fission (SF) candidates. By efficiently predicting excitation energies across 20 million molecules, and integrating TDDFT calculations, synthetic accessibility assessments, and GW+BSE calculations, this ...
Li Fu   +5 more
wiley   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn   +20 more
wiley   +1 more source

Stable olfactory receptor activation across odor complexity. [PDF]

open access: yesiScience
Kim M   +10 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

open access: yesAdvanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao   +3 more
wiley   +1 more source

Patch Testing in Chronic Hand Eczema: A Multicentre Study in Portugal. [PDF]

open access: yesContact Dermatitis
Martins AA   +6 more
europepmc   +1 more source

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