Results 41 to 50 of about 611,461 (294)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Health promotion of frail elderly individuals and at risk of frailty [PDF]

Revista Brasileira de Enfermagem, 2019
Objective: To identify interventions for the health promotion of frail elderly individuals and those at risk of frailty. Method: Integrative review of the literature performed in the following databases: LILACS, CINAHL, MEDLINE, Web of Science, COCHRANE
Cynthia Roberta Dias Torres Silva, Khelyane Mesquita de Carvalho, Maria do Livramento Fortes Figueiredo, Fernando Lopes Silva-Júnior, Elaine Maria Leite Rangel Andrade, Lydia Tolstenko Nogueira   +5 more
doaj   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study [PDF]

Brazilian Journal of Cardiovascular Surgery
Introduction: Frailty is a condition of elderly characterized by increased vulnerability to stressful events. Frail patients are more likely to have adverse events.
Caglar Ozmen, Ali Deniz, İmam Günay, İlker Ünal, Aziz Inan Celik, Çağlar Emre Çağlıyan, Onur Sinan Deveci, Mesut Demir, Mehmet Kanadaşı, Ayhan Usal   +9 more
doaj   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Frailty decreases physical health domain of quality of life in nursing home elderly

Universa Medicina, 2016
BACKGROUND Approximately 10-27% of the population aged >65 years suffers from frailty. The percentage increases with age so that the prevalence of frailty in the population aged >85 years reaches 45%.
Yvonne Suzy Handajani, Nelly Tina Widjaja, Yuda Turana   +2 more
doaj   +1 more source

A novel digital biomarker of sarcopenia in frail elderly: New combination of gait parameters under dual-task walking

Frontiers in Aging Neuroscience, 2023
BackgroundFrailty caused by deterioration in multiple physiological systems has led to a significant increase in adverse events such as falls, disability, and death in frail older people. Similar to frailty, sarcopenia, defined as loss of skeletal muscle
Zheping Zhou, Yulun Huang, Jing Wang, Huan Su, Haiying Tang, Yueju Wang   +5 more
doaj   +1 more source

Criteria for drug selection in frail elderly persons

, 2011
Background: Elderly patients with multiple morbidities and polypharmacy are at an increased risk of adverse drug events (ADEs). Appropriate prescribing, preserving the balance between drug effectiveness and safety, and treatment adherence may prevent ...
Van Marum, Rob J., Paul A.F. Jansen, Brouwers, J.R.B.J., Jacobus R.B.J. Brouwers, Rob J. van Marum, Van Roon, Eric N., Huisman-Baron, Marieke, Van Der Veen, Lucia, van Roon, E.N., Eric N. van Roon, Jansen, Paul A.F., Jansen, P.A.F., Brouwers, Jacobus R.B.J., van Roon, E.N.; id_orcid, Lucia van der Veen, Huisman-Baron, M., van der Veen, L., van Marum, R.J., Marieke Huisman-Baron   +18 more
core   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source