Results 131 to 140 of about 292,602 (339)

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

The Influence of Frailty on Cardiovascular Disease: The Time for a “Frailty Academic Research Consortium” Is Now! [PDF]

, 2022
Abdulla A. Damluji, Mauricio G. Cohen
openalex   +1 more source

Frailty in survival analysis models (parametric frailty, parametric shared frailty, and frailty in Cox models [PDF]

Frailty models are used to model survival times in the presence of overdispersion or group-specific random effects. The latter are distinguished from the former by the term "shared" frailty models.
Roberto G. Gutierrez
core  

Association of the clinical frailty scale with hospital outcomes. [PDF]

, 2015
BACKGROUND: The clinical frailty scale (CFS) was validated as a predictor of adverse outcomes in community-dwelling older people. In our hospital, the use of the CFS in emergency admissions of people aged ≥ 75 years was introduced under the Commissioning

core   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

The meaning of ‘quality’ of homecare for older people: a scoping review

BMC Health Services Research
Background How quality of care in homecare for older people is understood is important, because it influences how quality in homecare is delivered, improved, regulated and measured.
Alex Hall, Vanessa Davey, Lisa McGarrigle, Jayne Astbury, Kimberly Lazo Green, Nisar Ahmed, Oleta Williams, Fiona Beyer, Barbara Hanratty, Debora Price   +9 more
doaj   +1 more source

Frailty Predicts 30-day mortality following major complications in neurosurgery patients: The risk analysis index has superior discrimination compared to modified frailty index-5 and increasing patient age

World Neurosurgery: X
Background: Postoperative complications after cranial or spine surgery are prevalent, and frailty can be a key contributing patient factor. Therefore, we evaluated frailty’s impact on 30-day mortality.
Christopher C. Paiz, BS, Oluwafemi P. Owodunni, MD, MPH, Evan N. Courville, MD, Meic Schmidt, MD, MBA, Robert Alunday, MD, Christian A. Bowers   +5 more
doaj   +1 more source

Fighting Frailty with the Mediterranean Diet [PDF]

, 2018
It’s appropriate for each of us to examine our eating habits, not just our nutrition intake. The various aspects of the Mediterranean Diet hold potential benefits beyond the important feature of helping to reduce ...
Ansello, Edward F.
core   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

FRAILTY IN THE NORTH WEST ADELAIDE HEALTH STUDY USING THE FRAILTY PHENOTYPE AND INDEX APPROACHES [PDF]

, 2017
Mark Q Thompson, Olga Theou, S. Yu, Kylie Lange, R. Adams, Renuka Visvanathan   +5 more
openalex   +1 more source