Results 41 to 50 of about 1,043,400 (268)
Blazars define a stable celestial reference frame
Astronomy & AstrophysicsContext. Recent work has shown that optical-radio position offsets and radio position variability are inversely correlated with the optical photometric variability of active galactic nuclei (AGN).
Secrest N. J., Lambert S.
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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mSystemsA recent study by A. Bhosle, M. I. Jackson, A. M. Walsh, E. A. Franzosa, et al. (mSystems 10:e00452-24, 2024, https://doi.org/10.1128/msystems.00452-24) enhances our understanding of dietary fiber’s impact on the gut microbiome and metabolome in ...
Leigh A. Frame
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
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Lightweight bamboo structures - Report on 2021 International Collaboration on Bamboo Construction
Sustainable Structures, 2023 2021 International Collaboration on Bamboo Construction was held from September 1 to December 1, 2021. The practice was held by the College of Civil Engineering of Nanjing Forestry University, University College London, International Bamboo and Rattan ...
Assima Dauletbek +9 more
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
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MULTIAGENT APPROACH FOR MANAGING THE INFORMATION SPACE OF CORPORATE SYSTEMS
Сучасний стан наукових досліджень та технологій в промисловості, 2018 The subject matter of the study is the integration and management of information resources of distributed computing corporate systems within the common information space.
Valentin Filatov, Valerii Semenets
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
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Frontiers in Global Women's HealthBackgroundMaternal mortality in Ghana remains high at 263 deaths per 100,000 live births, with the Volta Region showing particularly concerning figures; 37.2% of women give birth without a skilled provider. Many rely on Traditional Birth Attendants (TBAs)
Sandrina Koppitz +3 more
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De l'expression du point de vue à l'anticipation textuelle : le rôle de à première vue
Discours, 2010 We propose a semantic and pragmatic analysis of the french locution à première vue (lit. “at first sight”) when it indicates a point of view (in the sense of Nølke, 1994) and plays a role in textual structuration (Charolles, 1997).
Véronique Lenepveu
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