Results 41 to 50 of about 1,624,385 (315)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Frame-Free Continuum Thermomechanics

, 2018
The principle of material frame-indifference is a fundamental concept in classical physics. In 1972 Walter Noll showed that one can formulate constitutive laws without using any external frames of reference.
Brian Seguin (5365004)
core   +1 more source

Frame Potentials and the Geometry of Frames [PDF]

Journal of Fourier Analysis and Applications, 2015
This paper concerns the geometric structure of optimizers for frame potentials. We consider finite, real or complex frames and rotation or unitarily invariant potentials, and mostly specialize to Parseval frames, meaning the frame potential to be optimized is a function on the manifold of Gram matrices belonging to finite Parseval frames.
Bodmann, Bernhard G., Haas, John
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The role of sexual preferences in intrasexual female competition

BMC Evolutionary Biology, 2012
Background While search costs have long been understood to affect the evolution of female preference, other costs associated with mating have been the focus of much less attention.
Frame Alicia M
doaj   +1 more source

Research into the Loading of the Tank Car Frame Concept with Filler in the Composite Center Sill

Communications, 2022
The study deals with determination of the dynamic loading on the frame of a tank car with closed composite center sill filled with elastic-viscous filler.
Oleksij Fomin, Juraj Gerlici, Alyona Lovska, Kateryna Kravchenko   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Frame approach to motivation of proper nouns

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Філологія. Vìsnik Harkìvsʹkogo nacìonalʹnogo unìversitetu ìmenì V.N. Karazìna. Serìâ Fìlologìâ., 2021
The author argues for frame approach to the analysis of proper names. It relies on the action-based conception of language, according to which meaning of words is formed in communication on the ground of subjective representations of entities of ...
Галина Вікторівна Зимовець
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Techniques of Frameless Robot-Assisted Deep Brain Stimulation and Accuracy Compared with the Frame-Based Technique

Brain Sciences, 2022
Background: Frameless robot-assisted deep brain stimulation (DBS) is an innovative technique for leads implantation. This study aimed to evaluate the accuracy and precision of this technique using the Sinovation SR1 robot.
Shanshan Mei, Kaijia Yu, Zhiwei Ren, Yongsheng Hu, Song Guo, Yongjie Li, Jianyu Li   +6 more
doaj   +1 more source