Results 81 to 90 of about 5,010,058 (349)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Frames, semi-frames, and Hilbert scales

, 2012
Given a total sequence in a Hilbert space, we speak of an upper (resp. lower) semi-frame if only the upper (resp. lower) frame bound is valid. Equivalently, for an upper semi-frame, the frame operator is bounded, but has an unbounded inverse, whereas a ...
Antoine, J-P., Balazs, P.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

From Naturalness to Environmental Control: Influences of Transitioning Production Systems on Dairy Farmers’ Perceptions of Cow Welfare

Animals
We conducted semi structured in-person interviews with 36 dairy farmers in a dairy producing region in southern Brazil undergoing intensification. Thematic analysis revealed that farmers’ perceptions of cow welfare were closely tied to their production ...
Letícia Bicudo Nogueira, Maria José Hötzel   +1 more
doaj   +1 more source

Fannie Mae's and Freddie Mac's voluntary initiatives: Lessons from banking [PDF]

The federal government has an interest in the financial stability of Fannie Mae and Freddie Mac because of their importance to financial markets and the government's implicit guarantee of their liabilities.
Larry Wall, W. Scott Frame
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Empirical studies of financial innovation: lots of talk, little action? [PDF]

This paper reviews the extant empirical studies of financial innovation. Adopting broad criteria, the authors found just two dozen studies, over half of which (fourteen) had been conducted since 2000. Since some financial innovations are examined by more
Lawrence J. White, W. Scott Frame
core  

From bench to bedside: Tracing the payback forwards from basic or early clinical research – A preliminary exercise and proposals for a future study [PDF]

, 2010
EXECUTIVE SUMMARY Chapter 1 : Introduction • The members of the research team from HERG and the Wellcome Trust have conducted previous studies showing that it is possible both to assess the payback from applied health research, and to use bibliometrics
Buxton, MJ, Frame, I, Grant, J, Green, P, Hanney, S   +4 more
core  

Some aspects of the cosmological conformal equivalence between ``Jordan Frame'' and ``Einstein Frame''

, 1996
The conformal equivalence between Jordan frame and Einstein frame can be used in order to search for exact solutions in general theories of gravity in which scalar fields are minimally or nonminimally coupled with geometry.
A A Marino, Barrow J, Bekenstein J D, Bergmann P G, Birrel N D, Brans C H, Callan C G, Capozziello S, Capozziello S, Capozziello S, Capozziello S, Capozziello S, Damour T, Eastwood M, Ferraris M, Ferraris M, Fierz M, Gradshteyn I S, Higgs P W, Jordan P, Jordan P, Kolb E W, Linde A D, Madsen M S, Magnano G, Mijic M B, Moffat J W, Moffat J W, Penrose R, R de Ritis, S Capozziello, Singh T, Sokolowski L M, Sonego S, Starobinskii A A, Synge J L, Wald R M, Whitt B, Will C M   +38 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source