Results 71 to 80 of about 2,188,737 (317)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

open access: yesFEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

Étude de l’activité évaluative de professeurs stagiaires confrontés à des productions d’élèves en mathématiques : quel référent pour l’évaluateur ?

open access: yesMesure et Évaluation en Éducation, 2007
Nous étudions l’activité évaluative de dix-huit professeurs stagiaires – professeurs des écoles (enseignement primaire) et professeurs de mathématiques (enseignement secondaire) – confrontés à des productions d’élèves en mathématiques.
Marc Vantourout
doaj   +1 more source

Assistant without Master? Some Conceptual Implications of Assistive Robotics in Health Care

open access: yesTechnologies, 2018
The subject of “technical assistants” in inpatient care is currently being widely discussed in scientific and public circles. In many cases, though, it has become apparent that the umbrella term “assistive technologies”, also in the context of robotics ...
Bettina-Johanna Krings, Nora Weinberger
doaj   +1 more source

Inner space: Reference frames [PDF]

open access: yesCurrent Biology, 2002
How are we aware of our surroundings? Somehow, from a pair of tiny, two-dimensional pictures of the visual world – provided by our retinas – our brains are able to render the world as it is, accurately depicting the locations of both a distant mountain range and the camera we are pointing at it.
openaire   +3 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

open access: yesFEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi   +4 more
wiley   +1 more source

Informational Reinterpretation of the Mechanics Notions and Laws

open access: yesEntropy, 2020
The informational re-interpretation of the basic laws of the mechanics exploiting the Landauer principle is suggested. When a physical body is in rest or it moves rectilinearly with the constant speed, zero information is transferred; thus, the ...
Edward Bormashenko
doaj   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

open access: yesFEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki   +11 more
wiley   +1 more source

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

open access: yesFEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang   +5 more
wiley   +1 more source

Integrating Multiple 3D Views through Frame-of-reference Interaction [PDF]

open access: yes, 2003
Frame-of-reference interaction consists of a unified set of 3D interaction techniques for exploratory navigation of large virtual spaces in nonimmersive environments.
Plumlee, Matthew D, Ware, Colin
core   +1 more source

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