Results 41 to 50 of about 527,994 (266)

Experimental Study of a New Self-Centering BRB and Its Application in Seismic Resistance of Frame Structure

Buildings
In order to enhance the self-centering capacity of steel frame structures after earthquakes and reduce the tubes of traditional double-tube or triple-tube SC-BRB, an innovative single-tube self-centering buckling restrained brace (ST-SC-BRB) is proposed ...
Yourong Lin, Zhi Zhou, Maoyu Shen, Jili Liu, Wei Huang   +4 more
doaj   +1 more source

A Seismic Checking Method of Engineering Structures Based on the Stochastic Semi-Physical Model of Seismic Ground Motions

Buildings, 2022
A seismic checking method of engineering structures based on the stochastic semi-physical model of seismic ground motions is developed. Four groups of stochastic ground motions are generated using the stochastic semi-physical model of seismic ground ...
Yanqiong Ding, Yazhou Xu, Huiquan Miao
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

SPECIFITIES OF EXPLICATION OF A BASIC COGNITIVE STRATEGY IN THE DISCOURSE SPACE OF GOOD WISHES [PDF]

Актуальные проблемы филологии и педагогической лингвистики, 2018
The article is devoted to identifying the specifics of the explication of the basic cognitive strategy in the discursive space of the good wishes of the Karachay-Balkarian language.
Gelayeva Ariuka I. , Huchinaeva Dzhamilya Dzh., Sabanchieva Asyat K.   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Buitetekste in 'n elektroniese gebaretaalwoordeboek

Lexikos, 2014
Outer Texts in an Electronic Sign Language Dictionary.The suggestions made in this article about outer texts in an electronic sign language dictionary serve as part of a complete concept model suggested specifically for the De la Bat School for the Deaf ...
Hanelle Fourie Blair
doaj   +1 more source

Numerical Analysis of Modified PVA Fiber Rubber Concrete in Frame Beams

Buildings, 2023
The feasibility of PVA fiber rubber concrete modified by modifier in the structure was investigated using the portal frame as the research object. The basic mechanical properties of modified PVA rubber concrete materials were tested mechanically first ...
Lijuan Li, Fang Xing, Zhijun Xu, Wang Chen, Wuxin Chen, Yongquan Li   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source