Results 51 to 60 of about 527,994 (266)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Theoretical and numerical modeling of a shallow foundation stiffness based on the theory of elastic half-space

Studia Geotechnica et Mechanica
The paper presents the derivation of equations for the calculation of the spring constants ky, kz, and kϕ and the spring coefficients βy, βz, and βϕ used in the modeling of a foundation with a rectangular base on elastic soil.
Pakos Wojciech, Helowicz Andrzej
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Enhancing Seismic Response in Frame Structures through Rigid Connections to Structures with Vibro-Impacting Mass

Applied Sciences
In this paper, a promising approach is studied that can efficiently mitigate seismic effects on a frame structure by coupling it with an protection system. Various devices are employed to achieve this objective, including tuned mass dampers, dynamic mass
Angelo Di Egidio, Alessandro Contento
doaj   +1 more source

Construction of Standard System Framework for Intelligent Agricultural Machinery in China

智慧农业, 2020
Standard system is the overall strategic planning and implementation guidance for standardization in professional field. In view of the missing of standard system on intelligent agricultural machinery, a standard system framework was contributed for the ...
HU Xiaolu, LIANG Xuexiu, ZHANG Junning, MEI Anjun, LYU Chengxu   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Experimental Study on Cracking of Aerated Concrete Filling Wall Under the Low Cyclic Horizontal Force

工程科学与技术, 2013
:In order to improve the seismic capacity of the aerated concrete infill walls, the mechanical properties of aerated concrete block and low cyclic horizontal force experiment of aerated concrete infill walls were studied.
王甲春, 曾骥, 张照华
doaj  

Improving the qualifications of doctors on the base of intelligent decision support systems

Adaptivni Sistemi Avtomatičnogo Upravlinnâ
The development of medical intelligent decision-making support systems (IDSS) provides an opportunity not only for advisory assistance at various stages of the medical and diagnostic process, but also the opportunity to improve the qualifications of ...
О. Стенін, В. Пасько, О. Лісовиченко, В. Солдатов   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source