Results 71 to 80 of about 17,672,271 (335)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A frame bundle generalization of multisymplectic field theories

, 1997
This paper presents a generalization of symplectic geometry to a principal bundle over the configuration space of a classical field. This bundle, the vertically adapted linear frame bundle, is obtained by breaking the symmetry of the full linear frame ...
Abraham, Awane, Bleecker, Cariñena, Fulp, Gotay, Gotay, Günther, J.K. Lawson, Kanatchikov, Kanatchikov, Kijowski, Kijowski, Kijowski, Kobayashi, Marsden, Marsden, Milnor, Norris, Norris, Norris, Ragionieri, Sardanashvily, Trautman   +23 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Theoretical and numerical modeling of a shallow foundation stiffness based on the theory of elastic half-space

Studia Geotechnica et Mechanica
The paper presents the derivation of equations for the calculation of the spring constants ky, kz, and kϕ and the spring coefficients βy, βz, and βϕ used in the modeling of a foundation with a rectangular base on elastic soil.
Pakos Wojciech, Helowicz Andrzej
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Enhancing Seismic Response in Frame Structures through Rigid Connections to Structures with Vibro-Impacting Mass

Applied Sciences
In this paper, a promising approach is studied that can efficiently mitigate seismic effects on a frame structure by coupling it with an protection system. Various devices are employed to achieve this objective, including tuned mass dampers, dynamic mass
Angelo Di Egidio, Alessandro Contento
doaj   +1 more source

Enabling Massive IoT in 5G and Beyond Systems: PHY Radio Frame Design Considerations

IEEE Access, 2016
The parameters of physical layer radio frame for 5th generation (5G) mobile cellular systems are expected to be flexibly configured to cope with diverse requirements of different scenarios and services.
Ayesha Ijaz, Lei Zhang, Maxime Grau, Abdelrahim Mohamed, Serdar Vural, Atta U. Quddus, Muhammad Ali Imran, Chuan Heng Foh, Rahim Tafazolli   +8 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Improving the qualifications of doctors on the base of intelligent decision support systems

Adaptivni Sistemi Avtomatičnogo Upravlinnâ
The development of medical intelligent decision-making support systems (IDSS) provides an opportunity not only for advisory assistance at various stages of the medical and diagnostic process, but also the opportunity to improve the qualifications of ...
О. Стенін, В. Пасько, О. Лісовиченко, В. Солдатов   +3 more
doaj   +1 more source

Structured Frames by Weil Entourages [PDF]

Applied Categorical Structures, 2000
Weil's original approach to uniform spaces through entourages of the diagonal and Tukey's via uniform covers are well documented in most books on the subject. On the other hand, in the pointfree context, the study of uniform frames and their generalizations has proceeded through uniform covers. The author of the present paper introduces Weil entourages
openaire   +2 more sources