Results 61 to 70 of about 93,836 (268)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fusion frames and g-frames

Journal of Mathematical Analysis and Applications, 2008
The authors study generalized, i.e., \(g\)-frames in a Hilbert space \(U\), that is, sequences \((\Lambda_i)_{i\in I}\) of linear operators \(\Lambda_i:U\to V_i\) such that \[ A\| f\| ^2 \leq \sum_{i\in I} \| \Lambda_i f\| ^2 \leq B \| f\| ^2, \] for some positive constants \(A\) and \(B\).
Khosravi, Amir, Musazadeh, Kamran
openaire   +1 more source

Popularizing the Internet

Nordicom Review, 2015
In popular science and technology writing, “boosterism” is prominent. Writers overwhelmingly describe science and technology in enthusiastic terms, thereby promoting the deficit or Public Appreciation of Science and Technology model (PAST).
Hetland Per
doaj   +1 more source

Framing the frame: How task goals determine the likelihood and direction of framing effects

Judgment and Decision Making, 2007
We examined how the goal of a decision task influences the perceived positive, negative valence of the alternatives and thereby the likelihood and direction of framing effects.
Todd McElroy, John J. Seta
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

On the duality of frames and fusion frames

Hacettepe Journal of Mathematics and Statistics, 2017
Optimal frame bounds play a key role in many applications of frame theory, such as filter banks. In this paper, we study the relation between the bounds of a frame and its alternate dual and then present some approach to construct a family of Parseval frames. Also, we survey some problems on duals of fusion frames.
AREFİJAMAAL, Ali Akbar, NEYSHABURİ, Fahimeh Arabyani, SHAMSABADİ, Mitra   +2 more
openaire   +3 more sources

Participation according to the law? The research-based knowledge on citizen participation in Norwegian municipal planning

European Journal of Spatial Development, 2018
Citizen participation is enshrined in the Norwegian Planning and Building Act (PBA) 1985 and accentuated by the 2008 revision of the PBA. In this article, we ask if the research on participation in municipal planning is sufficient to draw conclusions on
Toril Ringholm, Torill Nyseth, Gro Sandkjær Hanssen   +2 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source