Results 81 to 90 of about 54,900 (257)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Value Framing Effects on the Decision-Making Process: Ethical and Material Frames and Opinions About North Korean Nuclear Development

International Journal of Communication, 2016
Drawing on value frames frequently used in the current political discourse on North Korean nuclear aspirations, this study investigates how value framing affects people’s policy preference.
Jaeho Cho, Saifuddin Ahmed, Jung Won Park, Heejo Keum   +3 more
doaj  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Doubt Versus Trust: Framing Effects of the News About the 2018 Trump‒Kim Jong Un Summit in Singapore on American College Students

International Journal of Communication, 2020
This article examines the effects of trust versus doubt news frames during the 2018 denuclearization summit between the United States and North Korea in June 2018, an issue that is characterized by negative media coverage about North Korea and its leader
Chang Sup Park, Barbara K. Kaye
doaj  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Framing as a mechanism to overcome the temptation of bad habits

Frontiers in Behavioral Neuroscience
Behavioral neuroscience generally conceives of habits as under stimulus-response control, and distinguishes habits from goal-directed behavior based on their insensitivity to outcome value (features of automaticity). However, the everyday meaning of “bad
Shuning Wang, John Monterosso, John Monterosso, John Monterosso   +3 more
doaj   +1 more source

Neurophysiological Effects of Negotiation Framing. [PDF]

, 2016
In this study, we manipulated gain/loss framing context duringa simulated negotiation between a human user and a virtualagent. Task instructions placed users either in a loss or gainframed context, such that those in the loss frame had tominimize expenses whereas those in the gain frame had tomaximize profits.
Khooshabeh, Peter, Lin, Rebecca, Melo, Celso, Gratch, Jonathan, Ouimette, Brett, Blascovich, Jim   +5 more
openaire   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Time matters: on the predictive power of current, short- and long-term expected valence in an experience based learning task

Frontiers in Psychology
This study investigates the predictive power of current, short-, and long-term expected valence in decision-making within an experience-based learning task.
Daniel Thomas Jäger, Daniel Thomas Jäger, Jascha Rüsseler, Jascha Rüsseler   +3 more
doaj   +1 more source