Results 111 to 120 of about 9,565,371 (361)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Information Guide: Frankreich. February 2016 [PDF]

open access: yes, 2016
A guide to information sources on the Republic of France, with hyperlinks to information within European Sources Online and on external websites (For other language versions of this record click on the original ...
Cardiff EDC, .
core  

Lorentz Dynamics on Closed 3-Manifolds [PDF]

open access: yesarXiv, 2018
In this paper, we give a complete topological, as well as geometrical classification of closed 3-dimensional Lorentz manifolds admitting a noncompact isometry group.
arxiv  

High genetic carrier frequency of Wilson’s disease in France: discrepancies with clinical prevalence

open access: yesBMC Medical Genetics, 2018
BackgroundWilson’s disease (WD) is a rare autosomal recessive metabolic disease caused by ATP7B gene mutations tat cause excessively high copper levels, particularly in the liver and brain.
C. Collet   +5 more
semanticscholar   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

open access: yesMolecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song   +13 more
wiley   +1 more source

Profitability and Capital Structure: An Empirical Study of French and Hungarian Wine Producers in 2004-2013

open access: yesBusiness Systems Research, 2016
Background: Profitability of the Hungarian wine industry has been a focus of numerous research studies due to the centuries-old history and the recent changes.
Luptak Martin, Boda Daniel, Szucs Gabor
doaj   +1 more source

Worker mobility and the purchase of low CO2 emission vehicles in France: a datamining approach [PDF]

open access: yesThe European Journal of Comparative Economics, 2019
This paper seeks to pattern a non-driven geographical classification of French departmental territorial units based on both mobility behavior and passenger car fleet composition.
Raphaël Homayoun Boroumand   +3 more
doaj   +1 more source

XMM -Newton observations of merging clusters of galaxies: A3921 and A1750 [PDF]

open access: yesarXiv, 2002
We show the XMM-Newton guaranted time observations of 2 clusters of galaxies in a different stage of merger.
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Exposure of Wild Ungulates to the Usutu and Tick-Borne Encephalitis Viruses in France in 2009–2014: Evidence of Undetected Flavivirus Circulation a Decade Ago

open access: yesViruses, 2019
Flaviviruses have become increasingly important pathogens in Europe over the past few decades. A better understanding of the spatiotemporal distribution of flaviviruses in France is needed to better define risk areas and to gain knowledge of the dynamics
L. Bournez   +12 more
semanticscholar   +1 more source

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