Results 121 to 130 of about 9,565,371 (361)
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Algebraic Change-Point Detection [PDF]
Applicable Algebra in Engineering, Communication and Computing
(2010), 2009 Elementary techniques from operational calculus, differential algebra, and noncommutative algebra lead to a new approach for change-point detection, which is an important field of investigation in various areas of applied sciences and engineering. Several successful numerical experiments are presented.
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Correlations from ion-pairing and the Nernst-Einstein equation
, 2018 We present a new approximation to ionic conductivity well suited to dynamical atomic-scale simulations, based on the Nernst-Einstein equation. In our approximation, ionic aggregates constitute the elementary charge carriers, and are considered as non ...
France-Lanord, Arthur +1 more
core +1 more source
Vers une commande sans modèle pour aménagements hydroélectriques en cascade [PDF]
Sixi\`eme Conf\'erence Internationale Francophone d'Automatique
(CIFA 2010), Nancy : France (2010), 2010 A new concept called "Model-Free Control" is applied to hydroelectric run-of-the river power plants, with severe constraints and operating conditions. Numerous computer simulations display excellent results, which are obtained thanks to simple and robust algorithms.
arxiv
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Modular representations of p-adic groups
, 2002 I will survey some results in the theory of modular representations of a reductive $p$-adic group, in positive characteristic $\ell \neq p$ and $\ell=p$
Vignéras, Marie-France
core
France\u27s Financial Crisis: Analyzing the Role of the Finance Minister [PDF]
, 2015 The downfall of France\u27s Old Regime and the beginning of the French Revolution were largely caused by the financial crisis plaguing France. Since the Seven Year\u27s War, France\u27s finances had suffered and were spiraling out of control.
Smith, Jadon B
core +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Lacunary formal power series and the Stern-Brocot sequence
, 2013 Let $F(X) = \sum_{n \geq 0} (-1)^{\varepsilon_n} X^{-\lambda_n}$ be a real lacunary formal power series, where $\varepsilon_n = 0, 1$ and $\lambda_{n+1}/\lambda_n > 2$.
Allouche, Jean-Paul +1 more
core +3 more sources