Results 51 to 60 of about 351,531 (293)

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

A mise-en-scène do Estado Novo e os filmes premiados pelo DIP: reflexões metodológicas para uma análise

Fronteiras, 2010
Este artigo pretende discutir aspectos metodológicos e epistemológicos que permeiam a utilização de produtos culturais como fontes e objetos de estudo. Para tanto, mostra-se útil refletir sobre algumas abordagens específicas que se
Bianca Melyna Filgueira
doaj  

Sex differences in anxiety and depression: insights from adult rodent models of chronic stress and neural plasticity

Frontiers in Behavioral Neuroscience
The often co-morbid conditions of depression and anxiety are the most common mental illnesses and are more prevalent among females than males. Chronic stress paradigms in rodents serve as valuable preclinical models for investigating the factors ...
Rachel Bowman, Maya Frankfurt, Maya Frankfurt, Victoria Luine, Victoria Luine   +4 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Andreas Thier, Steuergesetzgebung und Verfassung in der konstitutionellen Monarchie. Staatssteuerreformen in Preußen 1871-1893,1999

Czasopismo Prawno-Historyczne, 2000
Recenzja: Andreas Thier, Steuergesetzgebung und Verfassung in der konstitutionellen Monarchie. Staatssteuerreformen in Preußen 1871-1893. Ius Commune.
Henryk Olszewski
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Das Corps Hassia zu Frankfurt am Main - ein Baustein zur frühen Nachkriegsgeschichte der Studentenverbindungen an der Universität Frankfurt am Main [PDF]

, 2013
Darstellung der Gründung des Frankfurter Corps Hassia 1949 nebst Mitgliederliste dieser Studentenverbindung. Überarbeitete und mit erläuternden Fußnoten versehene Fassung des Beitrags: Das Corps Hassia zu Frankfurt am Main, in: Einst und Jetzt ...
Herrlein, Jürgen
core  

Criticism of Mass Culture: The Frankfurt School Revisited

International Journal of Islamic Education, Research and Multiculturalism
Mazhab Frankfurt, dengan pendekatan kritisnya terhadap masyarakat kapitalis, telah memberikan kontribusi signifikan dalam memahami dinamika sosial. Penelitian ini bertujuan untuk menganalisis sejauh mana pemikiran Mazhab Frankfurt mempengaruhi gerakan ...
Muhammad Husni, Iskandar Zulkarnain, Mailin Mailin, Hakimatul Ubudiyah   +3 more
doaj   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source