Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Mai 1968 : 40 Jahre danach - und nun? ; Podiumsdiskussion an der Goethe-Universitaet Frankfurt am Main zwischen Daniel Cohn-Bendit (EU-Politiker) und Ulrich Oevermann (emeritierter Frankturter Soziologieprofessor) [PDF]
, 2008 Veranstaltet von der Deutsch-Franzoesischen Gesellschaft Frankfurt am Main e.V., dem Fachbereich Gesellschaftswissenschaften und dem Institut fuer Romanische Sprachen und Literaturen der Goethe-Universitaet, Frankfurt am Main.
Cohn-Bendit, Daniel +1 more
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Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Die von Uffenbach'schen Manuscripte auf der Stadtbibliothek zu Frankfurt a. M. [PDF]
, 2007 Zacharias Conrad von Uffenbach, Schöff und Rathsherr der Stadt Frankfurt am Main, geboren den 22. Februar 1683, hatte bekanntlich eine für die damalige Zeit sehr bedeutende Privatbibliothek zusammengebracht, und insbesondere weder Kosten noch Mühe ...
Kelchner, Ernst
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Verfassung des Freistaates Frankfurt : [Verfassungsentwurf] [PDF]
Die Verfassung des Freistaats Frankfurt beruht auf den Grundsätzen der Volkshoheit und Volksvertretung. ..
Frankfurt
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Modern Philosophy and Critical Theory in the Early Frankfurt School [PDF]
, 2019 The major theorists active at the Institut für Sozialforschung in Frankfurt from the 1920s onwards are known primarily as the thinkers who developed the concept of “critical theory”, which deals with the discovery of the mechanisms at work in the ...
Raffaele Carbone
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Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs
The Anatomical Record, EarlyView.Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille +6 more
wiley +1 more source
Postdramatic Theatre, 12 years later
Revista Brasileira de Estudos da Presença, 2013 This text takes stock of the twelve years of emergence of the practice and term Postdramatic and some of its developments and issues in the performing arts.
Hans-Thies Lehmann (Johann Wolfgang Goethe-Universität Frankfurt am Main – Frankfurt, Alemanha)
doaj
Doing One’s Best, Alternative Possibilities, and Blameworthiness
Crítica, 2018 My main aim in this paper is to improve and give further support to a defense of the Principle of Alternative Possibilities (PAP) against Frankfurt cases which I put forward in some previous work.
Carlos J. Moya
doaj +1 more source
The Anatomical Record, EarlyView.Abstract Neandertals are known to possess very distinctive traits in their bony labyrinth morphology, such as an inferiorly positioned posterior canal and a very low number of turns in the cochlea. Hence, the inner ear has been often used to assess the Neandertal status of fragmentary fossils.
Alessandro Urciuoli +6 more
wiley +1 more source