Isolation and Cultivation of Porcine Endothelial Cells, Pericytes and Astrocytes to Develop an In Vitro Blood–Brain Barrier Model for Drug Permeation Testing [PDF]
Pharmaceutics, 2023 The blood–brain barrier (BBB) is the bottleneck in the development of new drugs to reach the brain. Due to the BBB, toxic substances cannot enter the brain, but promising drug candidates also pass the BBB poorly.
Verena Ledwig, Stephan Reichl
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The Effect of Particle Shape on the Compaction of Realistic Non-Spherical Particles—A Multi-Contact DEM Study [PDF]
Pharmaceutics, 2023 The purpose of this study was to investigate the deformation behavior of non-spherical particles during high-load compaction using the multi-contact discrete element method (MC-DEM). To account for non-spherical particles, the bonded multi-sphere method (
Kostas Giannis +3 more
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Modeling of High-Density Compaction of Pharmaceutical Tablets Using Multi-Contact Discrete Element Method [PDF]
Pharmaceutics, 2021 The purpose of this work is to simulate the powder compaction of pharmaceutical materials at the microscopic scale in order to better understand the interplay of mechanical forces between particles, and to predict their compression profiles by ...
Kostas Giannis +3 more
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Modeling of physical-mechanical and microbiological properties of tablets made of complex fluidized bed granules containing living yeast cells using common mixing rules [PDF]
International Journal of Pharmaceutics: XIn order to administer probiotic microorganisms effectively, suitable dosage forms and production methods are required. These must be geared towards maintaining viability, which is essential for the health-promoting properties.
Karl Vorländer +4 more
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The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 2—Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing [PDF]
Pharmaceutics, 2023 The nasal mucosa, being accessible and highly vascularized, opens up new opportunities for the systemic administration of drugs. However, there are several protective functions like the mucociliary clearance, a physiological barrier which represents is a
Eugen Viktor Koch +5 more
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Tissue Barrier-on-Chip: A Technology for Reproducible Practice in Drug Testing [PDF]
Pharmaceutics, 2022 One key application of organ-on-chip systems is the examination of drug transport and absorption through native cell barriers such the blood–brain barrier.
Eugen V. Koch +4 more
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Embedding of Poorly Water-Soluble Drugs in Orodispersible Films—Comparison of Five Formulation Strategies [PDF]
Pharmaceutics, 2022 The poor bioavailability of many newly developed active pharmaceutical ingredients (APIs) poses a major challenge in formulation development. To overcome this issue, strategies such as the preparation of amorphous solid dispersions (ASDs), and the ...
Denise Steiner +2 more
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Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms during compaction? [PDF]
International Journal of Pharmaceutics: XThe provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation
Karl Vorländer +4 more
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2PP-Hydrogel Covered Electrodes to Compensate for Media Effects in the Determination of Biomass in a Capillary Wave Micro Bioreactor [PDF]
BiosensorsMicrobioreactors increase information output in biopharmaceutical screening applications because they can be operated in parallel without consuming large quantities of the pharmaceutical formulations being tested. A capillary wave microbioreactor (cwMBR)
Sven Meinen +6 more
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The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 1—Establishing a Nasal In Vitro Model for Drug Delivery Testing Based on a Novel Cell Line [PDF]
Pharmaceutics, 2023 In recent years, there has been a significant increase in the registration of drugs for nasal application with systemic effects. Previous preclinical in vitro test systems for transmucosal drug absorption studies have mostly been based on primary cells ...
Sebastian Bendas +5 more
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