Results 71 to 80 of about 5,555 (166)

Effects of Clarified Açaí Supplementation and Photobiomodulation on the Parotid Glands of Rats Submitted to Chemotherapy

Journal of Oral Pathology &Medicine, Volume 55, Issue 1, Page 120-132, January 2026.
ABSTRACT Background The antineoplastic drugs used in anticancer treatment regimens can induce changes in normal tissues, including salivary glands. This study evaluated the effects of clarified açaí and photobiomodulation (PBM) on the oxidative biochemistry and microstructure of the parotid glands of rats with oral mucositis. Methods Male rats (n = 54)
Wallacy Watson Pereira Melo, Walessa Alana Bragança Aragão, Maria Karolina Martins Ferreira, Vinicius Ruan Neves dos Santos, Leonardo Oliveira Bittencourt, Paulo Fernando Santos Mendes, Deborah Ribeiro Frazão, José Mário Matos‐Sousa, Hadassa Helez Neves Ferreira, José Messias Perdigão, Hannah Gil de Farias Morais, Herve Rogez, Roseana de Almeida Freitas, Manoela Domingues Martins, Rafael Rodrigues Lima, Renata Duarte de Souza‐Rodrigues   +15 more
wiley   +1 more source

Insights into the effects of Friedreich ataxia on the left ventricle using T1 mapping and late gadolinium enhancement.

PLoS ONE
BackgroundThe left ventricular (LV) changes which occur in Friedreich ataxia (FRDA) are incompletely understood.MethodsCardiac magnetic resonance (CMR) imaging was performed using a 1.5T scanner in subjects with FRDA who are homozygous for an expansion ...
Roger E Peverill, Kimberly Y Lin, Mark A Fogel, Michael M H Cheung, W Stuart Moir, Louise A Corben, Glenn Cahoon, Martin B Delatycki   +7 more
doaj   +1 more source

Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich’s ataxia

Disease Models & Mechanisms, 2012
SUMMARY Friedreich’s ataxia (FRDA) is the most common hereditary ataxia in the caucasian population and is characterized by a mixed spinocerebellar and sensory ataxia, hypertrophic cardiomyopathy and increased incidence of diabetes.
Alain Martelli, Lisa S. Friedman, Laurence Reutenauer, Nadia Messaddeq, Susan L. Perlman, David R. Lynch, Kathrin Fedosov, Jörg B. Schulz, Massimo Pandolfo, Hélène Puccio   +9 more
doaj   +1 more source

Somatic instability of the expanded GAA repeats in Friedreich's ataxia.

PLoS ONE, 2017
Friedreich's ataxia (FRDA) is a genetic neurodegenerative disorder caused by transcriptional silencing of the frataxin gene (FXN) due to expansions of GAA repeats in intron 1.
Ashlee Long, Jill S Napierala, Urszula Polak, Lauren Hauser, Arnulf H Koeppen, David R Lynch, Marek Napierala   +6 more
doaj   +1 more source

Anatomical and functional analysis of the corticospinal tract in an FRDA mouse model

Abstract Friedreich’s ataxia (FRDA) is one of the most common hereditary ataxias. It is caused by a GAA repeat in the first intron of the FXN gene, which encodes an essential mitochondrial protein. Patients suffer from progressive motor dysfunction due to the degeneration of mechanoreceptive and proprioceptive neurons in dorsal root ...
Nishiyama, Misa, Kalambogias, John, Imai, Fumiyasu, Yang, Emily, Lang, Sonia, de Nooij, Joriene C, Yoshida, Yutaka   +6 more
openaire   +2 more sources

Measuring peripheral nerve involvement in Friedreich’s ataxia

Annals of Clinical and Translational Neurology, 2019
Objective Experimental therapies under development for Friedreich’s Ataxia (FRDA) require validated biomarkers. In‐vivo reflectance confocal microscopy (RCM) of skin is a noninvasive way to quantify Meissner’s corpuscle (MC) density and has emerged as a ...
Peter D. Creigh, Joan Mountain, Janet E. Sowden, Katy Eichinger, Bernard Ravina, Jane Larkindale, David N. Herrmann   +6 more
doaj   +1 more source

Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.

PLoS ONE, 2017
IntroductionThe childhood heart disease of Friedreich's Ataxia (FRDA) is characterized by hypertrophy and failure. It is caused by loss of frataxin (FXN), a mitochondrial protein involved in energy homeostasis.
Amanda R Stram, Gregory R Wagner, Brian D Fogler, P Melanie Pride, Matthew D Hirschey, R Mark Payne   +5 more
doaj   +1 more source

Mapping the Friedreich ataxia locus (FRDA) by linkage disequilibrium analysis with highly polymorphic microsatellites

Biomedicine & Pharmacotherapy, 1994
The Friedreich's ataxia locus (FRDA) is tightly linked to markers D9S5 and D9S15 located in 9q13-q21. Cumulated maximum lod scores between FRDA and D9S5 and between FRDA and D9S15 are above 36 and 61, respectively, at a recombination fraction of 0, indicating that recombination events needed to orient the search of the gene are very difficult to ...
Sirugo, Giorgio, Duclos, Franck, Fujita, Ricardo, Keats, Bronya J.B., Pandolfo, Massimo, Mandel, Jean-Louis, Koenig, Michel   +6 more
openaire   +3 more sources

DNA Base Damage Repair Crosstalks with Chromatin Structures to Contract Expanded GAA Repeats in Friedreich’s Ataxia

Biomolecules
Trinucleotide repeat (TNR) expansion is the cause of over 40 neurodegenerative diseases, including Huntington’s disease and Friedreich’s ataxia (FRDA).
Yanhao Lai, Nicole Diaz, Rhyisa Armbrister, Irina Agoulnik, Yuan Liu   +4 more
doaj   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source