Results 121 to 130 of about 9,093,113 (302)

Correction: Fast and scalable solvent-free access to Lappert's heavier tetrylenes E{N(SiMe₃)₂}₂ (E = Ge, Sn, Pb) and ECl{N(SiMe₃)₂} (E = Ge, Sn). [PDF]

Chem Sci, 2023
Cabeza JA, Reynes JF, García F, García-Álvarez P, García-Soriano R.   +4 more
europepmc   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Free access to antiretroviral treatment and protection against the risk of catastrophic health expenditure in people living with HIV: evidence from Cameroon. [PDF]

BMC Health Serv Res, 2021
Bousmah MA, Nishimwe ML, Kuaban C, Boyer S.   +3 more
europepmc   +1 more source

A Country on the Move: Realities, Reform, and the Future of Rural to Urban Migration in China [PDF]

, 2007
This Article is brought to you for free and open access by the Inquiry Journal at University of New Hampshire Scholars ' Repository. It has been accepted for inclusion in Inquiry Journal 2007 by an authorized administrator of University of New ...
Pratt, Susannah
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

SKGRec: A Semantic-Enhanced Knowledge Graph Fusion Recommendation Algorithm with Multi-Hop Reasoning and User Behavior Modeling

Computers
To address the limitations of existing knowledge graph-based recommendation algorithms, including insufficient utilization of semantic information and inadequate modeling of user behavior motivations, we propose SKGRec, a novel recommendation model that ...
Siqi Xu, Ziqian Yang, Jing Xu, Ping Feng
doaj   +1 more source

The graphite-catalyzed ipso-functionalization of arylboronic acids in an aqueous medium: metal-free access to phenols, anilines, nitroarenes, and haloarenes. [PDF]

RSC Adv, 2021
Dandia A, Sharma R, Saini P, Badgoti RS, Rathore KS, Parewa V.   +5 more
europepmc   +1 more source

The EU Directive on Free Movement and Access to Social Benefits [PDF]

Wohnstandort, EU-Recht, Niederlassungsrecht, Freizügigkeit, Europäische Wirtschafts- und Währungsunion, Residential location, Community law, Freedom of establishment, Freedom of movement, European Economic and Monetary ...
Kay Hailbronner
core